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10.1126/science.1163493 http://scihub22266oqcxt.onion/10.1126/science.1163493 C2605283!2605283 !18974357     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18974357 &cmd=llinks): Failed to open stream: HTTP request failed! 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Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis |pdf=|usr=}}{{18974357 }} gab.com Text Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=18974357 #FOAvip The gene transient receptor potential-melastatin-like 7 (Trpm7) encodes a protein that functions as an ion channel and a kinase. TRPM7 has been proposed to be required for cellular Mg2+ homeostasis in vertebrates. Deletion of mouse Trpm7 revealed that it is essential for embryonic development. Tissue-specific deletion of Trpm7 in the T cell lineage disrupted thymopoiesis, which led to a developmental block of thymocytes at the double-negative stage and a progressive depletion of thymic medullary cells. However, deletion of Trpm7 in T cells did not affect acute uptake of Mg2+ or the maintenance of total cellular Mg2+. Trpm7-deficient thymocytes exhibited dysregulated synthesis of many growth factors that are necessary for the differentiation and maintenance of thymic epithelial cells. The thymic medullary cells lost signal transducer and activator of transcription 3 activity, which accounts for their depletion when Trpm7 is disrupted in thymocytes. Twit Text FOAVip Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis ????Science http://www.kidney.de/pget.php?&tw=1&pmid=18974357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18974357 #FOAvip English Wikipedia <ref>{{Cite pmid|18974357 }}</ref> Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis #MMPMID18974357 Jin J ; Desai BN ; Navarro B ; Donovan A ; Andrews NC ; Clapham DE Science 2008[Oct]; 322 (5902 ): 756-60 PMID18974357 show ga The gene transient receptor potential-melastatin-like 7 (Trpm7) encodes a protein that functions as an ion channel and a kinase. TRPM7 has been proposed to be required for cellular Mg2+ homeostasis in vertebrates. Deletion of mouse Trpm7 revealed that it is essential for embryonic development. Tissue-specific deletion of Trpm7 in the T cell lineage disrupted thymopoiesis, which led to a developmental block of thymocytes at the double-negative stage and a progressive depletion of thymic medullary cells. However, deletion of Trpm7 in T cells did not affect acute uptake of Mg2+ or the maintenance of total cellular Mg2+. Trpm7-deficient thymocytes exhibited dysregulated synthesis of many growth factors that are necessary for the differentiation and maintenance of thymic epithelial cells. The thymic medullary cells lost signal transducer and activator of transcription 3 activity, which accounts for their depletion when Trpm7 is disrupted in thymocytes. |*Embryonic Development [MESH] |*Lymphopoiesis [MESH] |Animals [MESH] |Gene Deletion [MESH] |Homeostasis [MESH] |Hyaluronan Receptors/metabolism [MESH] |Intercellular Signaling Peptides and Proteins/genetics/metabolism [MESH] |Interleukin-2 Receptor alpha Subunit/metabolism [MESH] |Magnesium/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Patch-Clamp Techniques [MESH] |STAT3 Transcription Factor/metabolism [MESH] |T-Lymphocytes/*cytology/immunology/*metabolism [MESH] |TRPM Cation Channels/genetics/*physiology [MESH]Deletion of Trpm7 disrupts embryonic development and thymopoiesis with(epmc).pdf DeepDyve Pubget Overpricing