Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\2985808
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Virol
1985 ; 54
(2
): 467-72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics
from rabbit leukocytes
#MMPMID2985808
Lehrer RI
; Daher K
; Ganz T
; Selsted ME
J Virol
1985[May]; 54
(2
): 467-72
PMID2985808
show ga
Six homologous peptides were purified to homogeneity from rabbit granulocytes or
alveolar macrophages and tested for their ability to inactivate herpes simplex
virus type 1 (HSV-1). Two of the peptides, MCP-1 and MCP-2, showed considerable
in vitro neutralizing activity, whereas four structurally homologous peptides
(NP-3a, NP-3b, NP-4, and NP-5) were relatively ineffective. Inactivation of HSV-1
by MCP-1 or MCP-2 depended on peptide concentration and on the time, temperature,
and pH of the incubation. HSV-2, vesicular stomatitis virus, and influenza virus
A/WSN were also susceptible to direct neutralization by MCP-1 or MCP-2, whereas
cytomegalovirus, echovirus type 11, and reovirus type 3 were not. We speculate
that MCP-1 and MCP-2, peptides that are abundant in rabbit granulocytes and lung
macrophages, may contribute to antiviral defenses by mediating the direct
inactivation of HSV-1 and selected other viruses.