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10.1128/JVI.54.2.467-472.1985

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suck abstract from ncbi


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pmid2985808
      J+Virol 1985 ; 54 (2 ): 467-72
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  • Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes #MMPMID2985808
  • Lehrer RI ; Daher K ; Ganz T ; Selsted ME
  • J Virol 1985[May]; 54 (2 ): 467-72 PMID2985808 show ga
  • Six homologous peptides were purified to homogeneity from rabbit granulocytes or alveolar macrophages and tested for their ability to inactivate herpes simplex virus type 1 (HSV-1). Two of the peptides, MCP-1 and MCP-2, showed considerable in vitro neutralizing activity, whereas four structurally homologous peptides (NP-3a, NP-3b, NP-4, and NP-5) were relatively ineffective. Inactivation of HSV-1 by MCP-1 or MCP-2 depended on peptide concentration and on the time, temperature, and pH of the incubation. HSV-2, vesicular stomatitis virus, and influenza virus A/WSN were also susceptible to direct neutralization by MCP-1 or MCP-2, whereas cytomegalovirus, echovirus type 11, and reovirus type 3 were not. We speculate that MCP-1 and MCP-2, peptides that are abundant in rabbit granulocytes and lung macrophages, may contribute to antiviral defenses by mediating the direct inactivation of HSV-1 and selected other viruses.
  • |Animals [MESH]
  • |Anti-Infective Agents/*pharmacology [MESH]
  • |Antimicrobial Cationic Peptides [MESH]
  • |Leukocytes/*analysis/immunology [MESH]
  • |Proteins/analysis/*pharmacology [MESH]
  • |Rabbits [MESH]
  • |Simplexvirus/drug effects [MESH]
  • |Structure-Activity Relationship [MESH]


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