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<script async src="//pagead2.googlesyndication.com/pagead/js/adsbygoogle.js"></script><!-- resp --><ins class="adsbygoogle"     style="display:block"     data-ad-client="ca-pub-1196903969644470"     data-ad-slot="9810425356"     data-ad-format="auto"></ins><script>(adsbygoogle = window.adsbygoogle || []).push({});</script></TD><TD WIDTH=60%><TABLE WIDTH=100% BORDER=0 BORDERCOLOR="#000000" CELLPADDING=4 CELLSPACING=0><TR VALIGN=TOP><TD WIDTH=50%><br><a href=http://scihub22266oqcxt.onion/10.1128/JVI.77.22.12222-12231.2003  target="_blank">http://scihub22266oqcxt.onion/10.1128/JVI.77.22.12222-12231.2003 </a><br><a href=http://scholar.google.de/scholar?as_q=Borna+Disease+Virus+Glycoprotein+Is+Required+for+Viral+Dissemination+in+Neurons+&as_sauthors= target="_blank"><IMG SRC="http://www.kidney.de/images/gspf.jpg" alt="suck pdf from google scholar" WIDTH=400 HEIGHT=50 BORDER=0></a><br><a href=http://sm.kidney.de/epmc.php?ep=eu&pmid=14581559&pmc=254271&ti=Borna%20Disease%20Virus%20Glycoprotein%20Is%20Required%20for%20Viral%20Dissemination%20in%20Neurons%20 target="_blank"><IMG SRC="http://www.kidney.de/images/europmc1.jpg" alt="unlimited free pdf from europmc14581559" WIDTH=250 HEIGHT=80 BORDER=0></a>&nbsp;&nbsp;&nbsp;<font size="+4"><i> free</i></font><br><a href=http://sm.kidney.de/epmc.php?ep=us&pmid=14581559&pmc=254271&ti=Borna%20Disease%20Virus%20Glycoprotein%20Is%20Required%20for%20Viral%20Dissemination%20in%20Neurons%20 target="_blank"><IMG SRC="https://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif" alt="PDF from PMC" WIDTH=250 HEIGHT=50 BORDER=0></a>&nbsp;&nbsp;&nbsp;<font size="+4"><i> free</i></font><br><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC254271/?report=classic"><IMG SRC="http://www.kidney.de/images/pmchtml.jpg" alt="html from PMC" WIDTH=250 HEIGHT=50 BORDER=0></a>&nbsp;&nbsp;&nbsp;<font size="+4"><i> free</i></font><br><A HREF=http://sm.kidney.de/epmc.php?ep=xx&li=http://jvi.asm.org/cgi/pmidlookupuripipliview=longuripiplypmid=14581559&ti=Borna%20Disease%20Virus%20Glycoprotein%20Is%20Required%20for%20Viral%20Dissemination%20in%20Neurons%20 TARGET="_blank"><IMG SRC="http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-standard-jvi_final_free.gif" alt="PDF vom PMID14581559" WIDTH=250 HEIGHT=50 BORDER=0></A>&nbsp:&nbsp;&nbsp;<font size="+4"><i> free</i></font><br><iframe src="http://www.kidney.de/popencheck.php?TA=J+Virol&DP=2003&MP=Nov&VO=77&VI=22&PG=12222-31&PMID=14581559" width="100%" height="100" frameborder="0" scrolling="auto"></iframe></TD><TD WIDTH=50%> <A href='https://twitter.com/intent/tweet?text=Borna Disease Virus Glycoprotein Is Required for Viral Dissemination in Neurons http%3A%2F%2Fwww.kidney.de%2Fpget.php%3F%26tw%3D1%26pmid%3D14581559+'><img src='http://www.kidney.de/images/twitter_bird_blue_48.png'></a><img src="http://www.kidney.de/phplern/14581559.jpg" alt="pmid14581559" WIDTH=40 HEIGHT=40 BORDER=0"><br>Nephropedia Template TP <br><textarea id="code" style="width: 100%; height: 80px; font-weight: bold;" >{{tp|p=14581559|t=2003. Borna Disease Virus Glycoprotein Is Required for Viral Dissemination in Neurons |pdf=|usr=}}</textarea><br>gab.com Text <br><textarea id="code" style="width: 100%; height: 20px" readonly>Borna Disease Virus Glycoprotein Is Required for Viral Dissemination in Neurons  JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=14581559 #FOAvip Borna disease virus (BDV) is a nonsegmented negative-strand RNA virus with a tropism for neurons. Infection with BDV causes neurological diseases in a wide variety of animal species. Although it is known that the virus spreads from neuron to neuron, assembled viral particles have never been visualized in the brains of infected animals. This has led to the hypothesis that BDV spreads as nonenveloped ribonucleoproteins (RNP) rather than as enveloped viral particles. We assessed whether the viral envelope glycoprotein (GP) is required for neuronal dissemination of BDV by using primary cultures of rat hippocampal neurons. We show that upon in vitro infection, BDV replicated and spread efficiently in this  system. Despite rapid virus dissemination, very few infectious viral particles were detectable in the culture. However, neutralizing antibodies directed against BDV-GP inhibited BDV spread. In addition, interference with BDV-GP processing by  inhibiting furin-mediated cleavage of the glycoprotein blocked virus spread. Finally, antisense treatment with peptide nucleic acids directed against BDV-GP mRNA inhibited BDV dissemination, marking BDV-GP as an attractive target for antiviral therapy against BDV. Together, our results demonstrate that the expression and correct processing of BDV-GP are necessary for BDV dissemination in primary cultures of rat hippocampal neurons, arguing against the hypothesis that the virus spreads from neuron to neuron in the form of nonenveloped RNP.</textarea><br>Twit Text FOAVip<br><textarea id="code" style="width: 100%; height: 20px" readonly>Borna Disease Virus Glycoprotein Is Required for Viral Dissemination in Neurons 🦆🦆J Virol http://www.kidney.de/pget.php?&tw=1&pmid=14581559 #FOAvip </textarea><br>Twit Text #<br><textarea id="code" style="width: 100%; height: 80px" readonly>Free Paper on
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LINK http://www.kidney.de/pget.php?&tw=1&pmid=14581559 #FOAvip</textarea><br>English Wikipedia<br><textarea id="code" style="width: 100%; height: 20px"; readonly><ref>{{Cite pmid|14581559}}</ref></textarea><br></TD></TR></TABLE><br><li><b>Borna Disease Virus Glycoprotein Is Required for Viral Dissemination in Neurons </b> #MMPMID14581559<li>Bajramovic JJ; Münter S; Syan S; Nehrbass U; Brahic M; Gonzalez-Dunia D<li>J Virol  2003[Nov]; 77 (22): 12222-31 PMID14581559garesp_yesshow ga

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