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10.1182/blood-2008-01-132860 http://scihub22266oqcxt.onion/10.1182/blood-2008-01-132860 C2518904!2518904!18544685     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Blood 2008 ; 112 (5): 2028-34 Nephropedia Template TP {{tp|p=18544685|t=2008. Toll-like receptor?mediated activation of neutrophils by influenza A virus |pdf=|usr=}}{{18544685}} gab.com Text Toll-like receptor mediated activation of neutrophils by influenza A virus JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=18544685 #FOAvip Influenza virus infection of the respiratory tract is characterized by a neutrophil infiltrate accompanied by inflammatory cytokine and chemokine production. We and others have reported that Toll-like receptor (TLR) proteins are present on human neutrophils and that granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment enhances IL-8 (CXCL8) secretion in response to stimulation with TLR ligands. We demonstrate that influenza virus can induce IL-8 and other inflammatory cytokines from GM-CSF?primed human neutrophils. Using heat inactivation of influenza virus, we show that viral entry but not replication is required for cytokine induction. Furthermore, endosomal acidification and viral uncoating are necessary. Finally, using single-cell analysis of intracellular cytokine accumulation in neutrophils from knockout mice, we prove that TLR7 is essential for influenza viral recognition and inflammatory cytokine production by murine neutrophils. These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response. Twit Text FOAVip Toll-like receptor mediated activation of neutrophils by influenza A virus ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=18544685 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18544685 #FOAvip English Wikipedia <ref>{{Cite pmid|18544685}}</ref> Toll-like receptor?mediated activation of neutrophils by influenza A virus #MMPMID18544685 Wang JP; Bowen GN; Padden C; Cerny A; Finberg RW; Newburger PE; Kurt-Jones EA Blood 2008[Sep]; 112 (5): 2028-34 PMID18544685show ga Influenza virus infection of the respiratory tract is characterized by a neutrophil infiltrate accompanied by inflammatory cytokine and chemokine production. We and others have reported that Toll-like receptor (TLR) proteins are present on human neutrophils and that granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment enhances IL-8 (CXCL8) secretion in response to stimulation with TLR ligands. We demonstrate that influenza virus can induce IL-8 and other inflammatory cytokines from GM-CSF?primed human neutrophils. Using heat inactivation of influenza virus, we show that viral entry but not replication is required for cytokine induction. Furthermore, endosomal acidification and viral uncoating are necessary. Finally, using single-cell analysis of intracellular cytokine accumulation in neutrophils from knockout mice, we prove that TLR7 is essential for influenza viral recognition and inflammatory cytokine production by murine neutrophils. These studies demonstrate neutrophil activation by influenza virus and highlight the importance of TLR7 and TLR8 in that response. äToll-like receptor?mediated activation of neutrophils by influenza A v(epmc).pdf DeepDyve Pubget Overpricing