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10.1371/journal.ppat.1000115 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1000115 C2483250!2483250 !18670648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=18670648 &cmd=llinks): Failed to open stream: HTTP request failed! 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H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice |pdf=|usr=}}{{18670648 }} gab.com Text H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=18670648 #FOAvip Fatal human respiratory disease associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate. Here, we quantified the cellular immune response to infection in the mouse lung by flow cytometry and demonstrate that mice infected with highly pathogenic (HP) H1N1 and H5N1 influenza viruses exhibit significantly high numbers of macrophages and neutrophils in the lungs compared to mice infected with low pathogenic (LP) viruses. Mice infected with the 1918 pandemic virus and a recent H5N1 human isolate show considerable similarities in overall lung cellularity, lung immune cell sub-population composition, and cellular immune temporal dynamics. Interestingly, while these similarities were observed, the HP H5N1 virus consistently elicited significantly higher levels of pro-inflammatory cytokines in whole lungs and primary human macrophages, revealing a potentially critical difference in the pathogenesis of H5N1 infections. Primary mouse and human macrophages and dendritic cells were also susceptible to 1918 and H5N1 influenza virus infection in vitro. These results together indicate that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP influenza virus infection. Twit Text FOAVip H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=18670648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18670648 #FOAvip English Wikipedia <ref>{{Cite pmid|18670648 }}</ref> H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice #MMPMID18670648 Perrone LA ; Plowden JK ; García-Sastre A ; Katz JM ; Tumpey TM PLoS Pathog 2008[Aug]; 4 (8 ): e1000115 PMID18670648 show ga Fatal human respiratory disease associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate. Here, we quantified the cellular immune response to infection in the mouse lung by flow cytometry and demonstrate that mice infected with highly pathogenic (HP) H1N1 and H5N1 influenza viruses exhibit significantly high numbers of macrophages and neutrophils in the lungs compared to mice infected with low pathogenic (LP) viruses. Mice infected with the 1918 pandemic virus and a recent H5N1 human isolate show considerable similarities in overall lung cellularity, lung immune cell sub-population composition, and cellular immune temporal dynamics. Interestingly, while these similarities were observed, the HP H5N1 virus consistently elicited significantly higher levels of pro-inflammatory cytokines in whole lungs and primary human macrophages, revealing a potentially critical difference in the pathogenesis of H5N1 infections. Primary mouse and human macrophages and dendritic cells were also susceptible to 1918 and H5N1 influenza virus infection in vitro. These results together indicate that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP influenza virus infection. |Adult [MESH] |Animals [MESH] |Dendritic Cells/*immunology/pathology [MESH] |Disease Outbreaks/history [MESH] |Female [MESH] |History, 20th Century [MESH] |Humans [MESH] |Influenza A Virus, H1N1 Subtype/immunology/pathogenicity [MESH] |Influenza A Virus, H5N1 Subtype/*immunology/pathogenicity [MESH] |Influenza, Human/history/*immunology/pathology [MESH] |Leukocytes/*immunology/pathology [MESH] |Lung/*immunology/pathology [MESH] |Male [MESH] |Mice [MESH]H5N1 and 1918 pandemic influenza virus infection results in early and (epmc).pdf DeepDyve Pubget Overpricing