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10.1164/rccm.200712-1839OC http://scihub22266oqcxt.onion/10.1164/rccm.200712-1839OC C2383992!2383992!18292469     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2008 ; 177 (10): 1103-10 Nephropedia Template TP {{tp|p=18292469|t=2008. Neonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice Infected with Influenza A Virus |pdf=|usr=}}{{18292469}} gab.com Text Neonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice Infected with Influenza A Virus JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=18292469 #FOAvip Rationale: Lungs of adult mice exposed to hyperoxia as newborns are simplified and exhibit reduced function much like that observed in people who had bronchopulmonary dysplasia (BPD) as infants. Because survivors of BPD also show increased risk for symptomatic respiratory infections, we investigated how neonatal hyperoxia affected the response of adult mice infected with influenza A virus infection.Objectives: To determine whether neonatal hyperoxia increased the severity of influenza A virus infection in adult mice.Methods: Adult female mice exposed to room air or hyperoxia between Postnatal Days 1 and 4 were infected with a sublethal dose of influenza A virus.Measurements and Main Results: The number of macrophages, neutrophils, and lymphocytes observed in airways of infected mice that had been exposed to hyperoxia as neonates was significantly greater than in infected siblings that had been exposed to room air. Enhanced inflammation correlated with increased levels of monocyte chemotactic protein-1 (CCL2) in lavage fluid, whereas infection-associated changes in IFN-?, IL-1?, IL-6, tumor necrosis factor-?, KC, granulocyte-macrophage colony?stimulating factor, and macrophage inflammatory protein-1?, and production of virus-specific antibodies, were largely unaffected. Increased mortality of mice exposed to neonatal hyperoxia occurred by Day 14 of infection, and was associated with persistent inflammation and fibrosis.Conclusions: These data suggest that the disruptive effect of hyperoxia on neonatal lung development also reprograms key innate immunoregulatory pathways in the lung, which may contribute to exacerbated pathology and poorer resistance to respiratory viral infections typically seen in people who had BPD. Twit Text FOAVip Neonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice Infected with Influenza A Virus ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=18292469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18292469 #FOAvip English Wikipedia <ref>{{Cite pmid|18292469}}</ref> Neonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice Infected with Influenza A Virus #MMPMID18292469 O'Reilly MA; Marr SH; Yee M; McGrath-Morrow SA; Lawrence BP Am J Respir Crit Care Med 2008[May]; 177 (10): 1103-10 PMID18292469show ga Rationale: Lungs of adult mice exposed to hyperoxia as newborns are simplified and exhibit reduced function much like that observed in people who had bronchopulmonary dysplasia (BPD) as infants. Because survivors of BPD also show increased risk for symptomatic respiratory infections, we investigated how neonatal hyperoxia affected the response of adult mice infected with influenza A virus infection.Objectives: To determine whether neonatal hyperoxia increased the severity of influenza A virus infection in adult mice.Methods: Adult female mice exposed to room air or hyperoxia between Postnatal Days 1 and 4 were infected with a sublethal dose of influenza A virus.Measurements and Main Results: The number of macrophages, neutrophils, and lymphocytes observed in airways of infected mice that had been exposed to hyperoxia as neonates was significantly greater than in infected siblings that had been exposed to room air. Enhanced inflammation correlated with increased levels of monocyte chemotactic protein-1 (CCL2) in lavage fluid, whereas infection-associated changes in IFN-?, IL-1?, IL-6, tumor necrosis factor-?, KC, granulocyte-macrophage colony?stimulating factor, and macrophage inflammatory protein-1?, and production of virus-specific antibodies, were largely unaffected. Increased mortality of mice exposed to neonatal hyperoxia occurred by Day 14 of infection, and was associated with persistent inflammation and fibrosis.Conclusions: These data suggest that the disruptive effect of hyperoxia on neonatal lung development also reprograms key innate immunoregulatory pathways in the lung, which may contribute to exacerbated pathology and poorer resistance to respiratory viral infections typically seen in people who had BPD. äNeonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice In(epmc).pdf DeepDyve Pubget Overpricing