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Characterization of a Borna disease virus glycoprotein, gp18 #MMPMID7933072
Kliche S; Briese T; Henschen AH; Stitz L; Lipkin WI
J Virol 1994[Nov]; 68 (11): 6918-23 PMID7933072show ga
Borna disease virus is a nonsegmented negative-strand RNA virus that causes neurologic disease in a wide variety of animal hosts. Here we describe identification and characterization of the first glycoprotein in this viral system. The 18-kDa glycoprotein, gp18, has been purified from infected rat brain. Isolation and microsequencing of this protein allowed identification of a 16.2-kDa open reading frame in the viral antigenome. Lectin binding and endoglycosidase sensitivity assays indicate that gp18 is an unusual N-linked glycoprotein.Images: