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suck abstract from ncbi


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pmid10449769      Proc+Natl+Acad+Sci+U+S+A 1999 ; 96 (17): 9769-74
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  • T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein #MMPMID10449769
  • Hausmann J; Hallensleben W; de la Torre JC; Pagenstecher A; Zimmermann C; Pircher H; Staeheli P
  • Proc Natl Acad Sci U S A 1999[Aug]; 96 (17): 9769-74 PMID10449769show ga
  • Infection of neonates with Borna disease virus (BDV) induces severe meningoencephalitis and neurological disorder in wild-type but not in ?2-microglobulin-deficient mice of strain MRL (H-2k). Temporary in vivo depletion of CD8+ T cells delayed BDV-induced disease for several weeks. Depletion of CD4+ T cells had a similar beneficial effect, indicating that the BDV-induced neurological disorder in mice is a CD4+ T cell-dependent immunopathological process that is mediated by CD8+ T cells. Lymphocytes prepared from brains of diseased mice were mainly from the CD8+ T cell subset. They showed up-regulation of activation markers and exerted strong MHC I-restricted cytotoxic activity against target cells expressing the BDV nucleoprotein p40. Infection of B10.BR (H-2k) or congenic C57BL/10 (H-2b) mice resulted in symptomless, lifelong persistence of BDV in the brain. Superinfection with a recombinant vaccinia virus expressing BDV p40 but not with other vaccinia viruses induced severe neurological disease and encephalitis in persistently infected B10.BR mice but not in persistently infected C57BL/10 mice, indicating that the disease-inducing T cell response is restricted to the nucleoprotein of BDV in H-2k mice. Our results demonstrate that the cellular arm of the immune system may ignore the presence of a replicating virus in the central nervous system until proper antigenic stimulation at a peripheral site triggers the antiviral response.
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