Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\9064338
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Exp+Med
1996 ; 184
(3
): 1191-6
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Selective induction of monocyte and not neutrophil-attracting chemokines after
influenza A virus infection
#MMPMID9064338
Sprenger H
; Meyer RG
; Kaufmann A
; Bussfeld D
; Rischkowsky E
; Gemsa D
J Exp Med
1996[Sep]; 184
(3
): 1191-6
PMID9064338
show ga
It is characteristic for virus infections that monocytes/macrophages and
lymphocytes infiltrate infected tissue while neutrophils are absent. To
understand the mechanisms selectively attracting mononuclear cells in viral
diseases, we examined in an influenza A virus model the expression and regulation
of chemokines as candidate molecules responsible for the immigration of
leukocytes into inflamed tissue. After influenza A virus infection of human
monocytes, a rapid expression of the mononuclear cell attracting CC-chemokine
genes MIP-1, MCP-1, and RANTES occurred which was followed by the release of
chemokine proteins. In striking contrast to CC-chemokines, the expression of the
prototype neutrophil CXC-chemoattractants IL-8 and GRO-alpha was completely
suppressed after influenza A infection. The release of other neutrophil
chemotactic factors was excluded by microchemotaxis assays. These results suggest
that the virus-specific induction of mononuclear cell-attracting chemokines
accounts for the preferential influx of mononuclear leukocytes into
virus-infected tissue.