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1986 ; 163
(3
): 511-9
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Interleukin 1 and interleukin 1 inhibitor production by human macrophages exposed
to influenza virus or respiratory syncytial virus Respiratory syncytial virus is
a potent inducer of inhibitor activity
#MMPMID3485170
Roberts NJ Jr
; Prill AH
; Mann TN
J Exp Med
1986[Mar]; 163
(3
): 511-9
PMID3485170
show ga
Respiratory viral infections are commonly associated with altered immune
responses, such as proliferative responses to mitogens and antigens. To examine
potential mechanisms, we examined production of IL-1 and IL-1 inhibitors by
purified human peripheral blood-derived macrophages exposed to influenza virus or
respiratory syncytial virus (RSV). IL-1 and IL-1 inhibitor activities in
supernatant fluids from macrophages exposed to the viruses 24 h previously were
measured using the standard mouse thymocyte comitogen assay. Crude fluids from
macrophages exposed to influenza virus contained substantial IL-1 activity,
whereas crude fluids from macrophages exposed to RSV contained marked IL-1
inhibitor activity. Assays with gel filtration-separated fractions revealed that
both influenza virus and RSV induced production of both IL-1 and IL-1 inhibitors.
Neither IL-2 nor IL-2 inhibitor activities were detected. Thus, effects of human
macrophage-derived factors on thymocyte proliferation, or potentially on human
lymphocyte proliferation, may reflect the total or net activity of multiple
composite factors, the balance of which varies according to the challenge. The
data raise the possibility that marked production of IL-1 inhibitor activity in
response to RSV plays a role in the clinical recurrence of RSV infection despite
the absence of clear evidence for antigenic shift or drift of the virus.