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1981 ; 154
(1
): 199-203
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Virus-specific interferon action Protection of newborn Mx carriers against
lethal infection with influenza virus
#MMPMID6166723
Haller O
; Arnheiter H
; Gresser I
; Lindenmann J
J Exp Med
1981[Jul]; 154
(1
): 199-203
PMID6166723
show ga
The efficacy of interferon in antiviral protection of newborn mice differing at
the Mx locus was investigated. Adult mice bearing the allele Mx exhibit a high
degree of specific resistance toward lethal challenge with influenza viruses. In
contrast, newborn Mx carriers are virtually as susceptible to influenza viruses
as newborn mice devoid of Mx. Resistance can be abrogated by treating adult
animals with anti-interferon serum. Here, we provide direct evidence of a
virus-specific effect of interferon in vivo: newborn mice carrying the resistance
gene Mx could be protected against lethal influenza virus infection with doses of
interferon that were not protective in the absence of Mx. The efficacy of
interferon towards a picornavirus (encephalomyocarditis virus) and a rhabdovirus
(vesicular stomatitis virus) was independent of Mx.