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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Exp+Med
1979 ; 150
(1
): 117-26
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Natural, genetically determined resistance toward influenza virus in hemopoietic
mouse chimeras Role of mononuclear phagocytes
#MMPMID36443
Haller O
; Arnheiter H
; Lindenmann J
J Exp Med
1979[Jul]; 150
(1
): 117-26
PMID36443
show ga
Radiation chimeras produced by crosswise transfers of bone-marrow cell among
histocompatible mice susceptible, or genetically resistant, to lethal challenge
by a number of myxoviruses were used to test whether macrophage resistance (as
assessed in vitro) and resistance of the animal (as measured in vivo), both
previously shown to be brought about by the gene Mx, were causally related. 49
chimeras were tested individually, both of resistance of their macrophages to in
vitro challenge with M-TUR (a strain of avian influenza virus A/Turkey/England/63
adapted to grow in cultured mouse peritoneal macrophages), and for resistance of
the animal in vivo upon challenge with pneumotropic, neurotropic, or hepatotropic
influenza viruses. Cultivated Kupffer cells and peritoneal macrophages harvested
from chimeric mice expressed the resistance phenotype of the bone-marrow donor
irrespective of the host environment in which they had differentiated. However,
susceptibility or resistance in vivo was according to the genotype of the host.
Thus, inborn resistance of radiation chimeras was found to be independent of
Mx-gene expression in cells of the hemopoietic system.