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10.1038/nm1609 http://scihub22266oqcxt.onion/10.1038/nm1609 C2135607!2135607!17603493     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2007 ; 13 (7): 828-35 Nephropedia Template TP {{tp|p=17603493|t=2007. Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer |pdf=|usr=}}{{17603493}} gab.com Text Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=17603493 #FOAvip Antigen-specific CD8+ T-cell tolerance is one of the major mechanisms of tumor escape. Recent studies have shown that this tolerance was induced by myeloid-derived suppressor cells (MDSC). Using in vivo models we have found that MDSC directly disrupted the binding of the specific peptide-MHC (pMHC) dimers to CD8+ T cells via nitration of tyrosines within TCR/CD8 complex, which resulted in the inability of CD8+ T cells to bind pMHC and respond to the specific peptide. These cells retained their ability to respond to non-specific stimulation. Nitration of TCR/CD8 was induced by MDSC via hyperproduction of reactive oxygen species (ROS) and peroxynitrite during direct cell-cell contact. Molecular modeling suggested specific sites of nitration that could affect conformational flexibility of TCR/CD8 and its interaction with pMHC. This data demonstrates novel mechanisms of T-cell tolerance in cancer that also can be pertinent to many pathological conditions associated with accumulation of MDSC. Twit Text FOAVip Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=17603493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17603493 #FOAvip English Wikipedia <ref>{{Cite pmid|17603493}}</ref> Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer #MMPMID17603493 Nagaraj S; Gupta K; Pisarev V; Kinarsky L; Sherman S; Kang L; Herber D; Schneck J; Gabrilovich DI Nat Med 2007[Jul]; 13 (7): 828-35 PMID17603493show ga Antigen-specific CD8+ T-cell tolerance is one of the major mechanisms of tumor escape. Recent studies have shown that this tolerance was induced by myeloid-derived suppressor cells (MDSC). Using in vivo models we have found that MDSC directly disrupted the binding of the specific peptide-MHC (pMHC) dimers to CD8+ T cells via nitration of tyrosines within TCR/CD8 complex, which resulted in the inability of CD8+ T cells to bind pMHC and respond to the specific peptide. These cells retained their ability to respond to non-specific stimulation. Nitration of TCR/CD8 was induced by MDSC via hyperproduction of reactive oxygen species (ROS) and peroxynitrite during direct cell-cell contact. Molecular modeling suggested specific sites of nitration that could affect conformational flexibility of TCR/CD8 and its interaction with pMHC. This data demonstrates novel mechanisms of T-cell tolerance in cancer that also can be pertinent to many pathological conditions associated with accumulation of MDSC. äAltered recognition of antigen is a novel mechanism of CD8+ T cell tol(epmc).pdf DeepDyve Pubget Overpricing