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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Br+J+Cancer
1975 ; 31
(5
): 528-34
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Cellular immunity to myelin basic protein in man and in animal model systems as
measured by the macrophage migration inhibition test
#MMPMID50855
Shelton JB
; Potter CW
; Carr I
Br J Cancer
1975[May]; 31
(5
): 528-34
PMID50855
show ga
Lymphocytes from patients with neoplastic disease were tested for sensitization
to encephalitogenic factor (EF) by the macrophage migration inhibition test.
Sensitization to EF was demonstrated in 71% of patients with various forms of
neoplastic disease. Sensitization to EF was also demonstrated for 31% of subjects
with no evidence of neoplastic disease; these included patients with warts,
chronic bronchitis and hernias. In contrast, healthy subjects showed no
sensitization to myelin basic protein. These observations suggest that
sensitization to EF may not be confined to patients with neoplastic disease.
Lymphocytes from hamsters bearing a transplanted virus induced tumour were
sensitized to EF prepared from both human and hamster brain. Sensitization was
also seen in hamsters infected with influenza virus but not in animals with acute
tubular necrosis produced by glycerol treatment. The development of an animal
model system provides a method for the investigation of possible mechanisms of
sensitization.