Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1172/JCI31680 http://scihub22266oqcxt.onion/10.1172/JCI31680 C1934557!1934557!17671655     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Invest 2007 ; 117 (8): 2260-7 Nephropedia Template TP {{tp|p=17671655|t=2007. Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia |pdf=|usr=}}{{17671655}} gab.com Text Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=17671655 #FOAvip Primary hypomagnesemia constitutes a rare heterogeneous group of disorders characterized by renal or intestinal magnesium (Mg2+) wasting resulting in generally shared symptoms of Mg2+ depletion, such as tetany and generalized convulsions, and often including associated disturbances in calcium excretion. However, most of the genes involved in the physiology of Mg2+ handling are unknown. Through the discovery of a mutation in the EGF gene in isolated autosomal recessive renal hypomagnesemia, we have, for what we believe is the first time, identified a magnesiotropic hormone crucial for total body Mg2+ balance. The mutation leads to impaired basolateral sorting of pro-EGF. As a consequence, the renal EGFR is inadequately stimulated, resulting in insufficient activation of the epithelial Mg2+ channel TRPM6 (transient receptor potential cation channel, subfamily M, member 6) and thereby Mg2+ loss. Furthermore, we show that colorectal cancer patients treated with cetuximab, an antagonist of the EGFR, develop hypomagnesemia, emphasizing the significance of EGF in maintaining Mg2+ balance. Twit Text FOAVip Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=17671655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=17671655 #FOAvip English Wikipedia <ref>{{Cite pmid|17671655}}</ref> Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia #MMPMID17671655 Groenestege WMT; Thébault S; van der Wijst J; van den Berg D; Janssen R; Tejpar S; van den Heuvel LP; van Cutsem E; Hoenderop JG; Knoers NV; Bindels RJ J Clin Invest 2007[Aug]; 117 (8): 2260-7 PMID17671655show ga Primary hypomagnesemia constitutes a rare heterogeneous group of disorders characterized by renal or intestinal magnesium (Mg2+) wasting resulting in generally shared symptoms of Mg2+ depletion, such as tetany and generalized convulsions, and often including associated disturbances in calcium excretion. However, most of the genes involved in the physiology of Mg2+ handling are unknown. Through the discovery of a mutation in the EGF gene in isolated autosomal recessive renal hypomagnesemia, we have, for what we believe is the first time, identified a magnesiotropic hormone crucial for total body Mg2+ balance. The mutation leads to impaired basolateral sorting of pro-EGF. As a consequence, the renal EGFR is inadequately stimulated, resulting in insufficient activation of the epithelial Mg2+ channel TRPM6 (transient receptor potential cation channel, subfamily M, member 6) and thereby Mg2+ loss. Furthermore, we show that colorectal cancer patients treated with cetuximab, an antagonist of the EGFR, develop hypomagnesemia, emphasizing the significance of EGF in maintaining Mg2+ balance. äImpaired basolateral sorting of pro-EGF causes isolated recessive rena(epmc).pdf DeepDyve Pubget Overpricing