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10.1128/JVI.02468-06

http://scihub22266oqcxt.onion/10.1128/JVI.02468-06
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C1933315!1933315!17428855
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suck abstract from ncbi


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pmid17428855      J+Virol 2007 ; 81 (13): 7297-9
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  • The X Protein of Borna Disease Virus Serves Essential Functions in the Viral Multiplication Cycle? #MMPMID17428855
  • Poenisch M; Wille S; Ackermann A; Staeheli P; Schneider U
  • J Virol 2007[Jul]; 81 (13): 7297-9 PMID17428855show ga
  • The X gene of Borna disease virus (BDV) encodes a nonstructural 10-kDa protein that can interact with viral polymerase cofactor P, thus regulating polymerase activity. It remained unknown whether X is essential for virus multiplication. All our attempts to generate mutant BDV with a nonfunctional X gene proved unsuccessful. However, a mutant virus with an inactive X gene was able to replicate in Vero cells if an artificial gene cassette encoding X was inserted at a site near the 5? end of the viral genome. These results indicate that X performs essential viral functions.
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