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2000 ; 119
(2
): 287-92
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Fish oil feeding enhances lymphocyte proliferation but impairs virus-specific T
lymphocyte cytotoxicity in mice following challenge with influenza virus
#MMPMID10632664
Byleveld M
; Pang GT
; Clancy RL
; Roberts DC
Clin Exp Immunol
2000[Feb]; 119
(2
): 287-92
PMID10632664
show ga
The effect of a fish oil diet on virus-specific cytotoxicity and lymphocyte
proliferation was investigated. Mice were fed fish oil (17 g fish oil and 3 g
sunflower/100 g) or beef tallow (17 g tallow and 3 g sunflower/100 g) diets for
14 days before intranasal challenge with influenza virus. At day 5 after
infection, lung virus-specific T lymphocyte, but not macrophage or natural killer
(NK) cell, cytotoxicity was significantly lower in mice fed fish oil, while
bronchial lymph node cell proliferation to virus was significantly higher. In
mice fed fish oil, spleen cell proliferation to virus was also significantly
higher following immunization. The results showed that, despite improved
lymphocyte proliferation, fish oil impairs primary virus-specific T lymphocyte
cytotoxicity. This impairment may explain the delayed virus clearance that we
have previously reported in infected mice fed the fish oil diet.