Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 280.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\17376896
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Virol
2007 ; 81
(11
): 5940-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Downregulation of an astrocyte-derived inflammatory protein, S100B, reduces
vascular inflammatory responses in brains persistently infected with Borna
disease virus
#MMPMID17376896
Ohtaki N
; Kamitani W
; Watanabe Y
; Hayashi Y
; Yanai H
; Ikuta K
; Tomonaga K
J Virol
2007[Jun]; 81
(11
): 5940-8
PMID17376896
show ga
Borna disease virus (BDV) is a neurotropic virus that causes a persistent
infection in the central nervous system (CNS) of many vertebrate species.
Although a severe reactive gliosis is observed in experimentally BDV-infected rat
brains, little is known about the glial reactions contributing to the viral
persistence and immune modulation in the CNS. In this regard, we examined the
expression of an astrocyte-derived factor, S100B, in the brains of Lewis rats
persistently infected with BDV. S100B is a Ca(2+)-binding protein produced mainly
by astrocytes. A prominent role of this protein appears to be the promotion of
vascular inflammatory responses through interaction with the receptor for
advanced glycation end products (RAGE). Here we show that the expression of S100B
is significantly reduced in BDV-infected brains despite severe astrocytosis with
increased glial fibrillary acidic protein immunoreactivity. Interestingly, no
upregulation of the expression of S100B, or RAGE, was observed in the
persistently infected brains even when incited with several inflammatory stimuli,
including lipopolysaccharide. In addition, expression of the vascular cell
adhesion molecule 1 (VCAM-1), as well as the infiltration of encephalitogenic T
cells, was significantly reduced in persistently infected brains in which an
experimental autoimmune encephalomyelitis was induced by immunization with
myelin-basic protein. Furthermore, we demonstrated that the continuous activation
of S100B in the brain may be necessary for the progression of vascular immune
responses in neonatally infected rat brains. Our results suggested that BDV
infection may impair astrocyte functions via a downregulation of S100B
expression, leading to the maintenance of a persistent infection.