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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Virol
1996 ; 70
(2
): 1288-91
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Immune CD4+ T cells promote the clearance of influenza virus from major
histocompatibility complex class II -/- respiratory epithelium
#MMPMID8551597
Topham DJ
; Tripp RA
; Sarawar SR
; Sangster MY
; Doherty PC
J Virol
1996[Feb]; 70
(2
): 1288-91
PMID8551597
show ga
The experiments described establish that CD4+ T-cell-dependent effector
mechanisms can eliminate an H3N2 influenza A virus from lung cells that are
unable to express class II major histocompatibility complex (MHC) glycoproteins.
Radiation chimeras were made by using CD4+ T cells and bone marrow from
CD8-depleted, MHC class II +/+ mice and irradiated (950 rads) MHC class II -/-
recipients. The influenza virus-specific CD4+ T-cell responses in these +/+-->-/-
mice were not obviously different from those in the +/+-->+/+ controls: the
cytokine profiles, the spectra of plasma cells producing the various
immunoglobulin isotypes, and the frequencies of virus-specific CD4+ T cells were
similar for the two groups. Expression of class II MHC glycoproteins on
stimulator cells, B lymphocytes, and monocytes/macrophages is apparently
sufficient for CD4+ T cells to terminate influenza virus infection of MHC class
II -/- respiratory epithelium. A possible explanation is that the local spread of
this lytic virus in the lung is limited by cytokines and/or antibody.