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10.1046/j.1365-2567.2003.01636.x http://scihub22266oqcxt.onion/10.1046/j.1365-2567.2003.01636.x C1782947!1782947!12709019     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2003 ; 109 (1): 68-75 Nephropedia Template TP {{tp|p=12709019|t=2003. The influence of macrophage inflammatory protein-1? on protective immunity mediated by antiviral cytotoxic T cells |pdf=|usr=}}{{12709019}} gab.com Text The influence of macrophage inflammatory protein-1 on protective immunity mediated by antiviral cytotoxic T cells JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=12709019 #FOAvip Macrophage inflammatory protein 1? (MIP-1?), a member of the CC-chemokine subfamily, is known to induce chemotaxis of a variety of cell types in vivo. Although the role of MIP-1? in inflammatory responses generated following primary infection of mice with many different pathogens has been characterized, the influence of this chemokine on the generation of antigen-specific T-cell responses in vivo is less well understood. This is important, as virus-specific CD8+ T lymphocytes (CTL) play a crucial role in defence against viral infections, both acutely and in the long term. In this study, we compared the ability of wild-type and MIP-1?-deficient (MIP-1??/?) mice to mount CTL responses specific for the immunodominant epitope derived from influenza nucleoprotein (NP366?374). Influenza-specific CTL responses were compared with respect to frequency, cytotoxic activity and ability to clear subsequent infections with recombinant vaccinia viruses expressing the influenza NP. The results indicate that antiviral CTL generated in MIP-1??/? mice are slightly impaired in their ability to protect against a subsequent infection. However, impaired in vivo CTL-mediated antiviral protection was found to be associated with reduced cytotoxicity rather than with a failure of the CTL to migrate to peripheral sites of infection. Twit Text FOAVip The influence of macrophage inflammatory protein-1 on protective immunity mediated by antiviral cytotoxic T cells ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=12709019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12709019 #FOAvip English Wikipedia <ref>{{Cite pmid|12709019}}</ref> The influence of macrophage inflammatory protein-1? on protective immunity mediated by antiviral cytotoxic T cells #MMPMID12709019 Jones E; Price DA; Dahm-Vicker M; Cerundolo V; Klenerman P; Gallimore A Immunology 2003[May]; 109 (1): 68-75 PMID12709019show ga Macrophage inflammatory protein 1? (MIP-1?), a member of the CC-chemokine subfamily, is known to induce chemotaxis of a variety of cell types in vivo. Although the role of MIP-1? in inflammatory responses generated following primary infection of mice with many different pathogens has been characterized, the influence of this chemokine on the generation of antigen-specific T-cell responses in vivo is less well understood. This is important, as virus-specific CD8+ T lymphocytes (CTL) play a crucial role in defence against viral infections, both acutely and in the long term. In this study, we compared the ability of wild-type and MIP-1?-deficient (MIP-1??/?) mice to mount CTL responses specific for the immunodominant epitope derived from influenza nucleoprotein (NP366?374). Influenza-specific CTL responses were compared with respect to frequency, cytotoxic activity and ability to clear subsequent infections with recombinant vaccinia viruses expressing the influenza NP. The results indicate that antiviral CTL generated in MIP-1??/? mice are slightly impaired in their ability to protect against a subsequent infection. However, impaired in vivo CTL-mediated antiviral protection was found to be associated with reduced cytotoxicity rather than with a failure of the CTL to migrate to peripheral sites of infection. äThe influence of macrophage inflammatory protein-1? on protective immu(epmc).pdf DeepDyve Pubget Overpricing