Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\12709019
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Immunology
2003 ; 109
(1
): 68-75
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The influence of macrophage inflammatory protein-1alpha on protective immunity
mediated by antiviral cytotoxic T cells
#MMPMID12709019
Jones E
; Price DA
; Dahm-Vicker M
; Cerundolo V
; Klenerman P
; Gallimore A
Immunology
2003[May]; 109
(1
): 68-75
PMID12709019
show ga
Macrophage inflammatory protein 1alpha (MIP-1alpha), a member of the CC-chemokine
subfamily, is known to induce chemotaxis of a variety of cell types in vivo.
Although the role of MIP-1alpha in inflammatory responses generated following
primary infection of mice with many different pathogens has been characterized,
the influence of this chemokine on the generation of antigen-specific T-cell
responses in vivo is less well understood. This is important, as virus-specific
CD8+ T lymphocytes (CTL) play a crucial role in defence against viral infections,
both acutely and in the long term. In this study, we compared the ability of
wild-type and MIP-1alpha-deficient (MIP-1alpha-/-) mice to mount CTL responses
specific for the immunodominant epitope derived from influenza nucleoprotein
(NP366-374). Influenza-specific CTL responses were compared with respect to
frequency, cytotoxic activity and ability to clear subsequent infections with
recombinant vaccinia viruses expressing the influenza NP. The results indicate
that antiviral CTL generated in MIP-1alpha-/- mice are slightly impaired in their
ability to protect against a subsequent infection. However, impaired in vivo
CTL-mediated antiviral protection was found to be associated with reduced
cytotoxicity rather than with a failure of the CTL to migrate to peripheral sites
of infection.