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10.1111/j.1365-2567.2004.02000.x http://scihub22266oqcxt.onion/10.1111/j.1365-2567.2004.02000.x C1782065!1782065!15606801     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2005 ; 114 (1): 112-20 Nephropedia Template TP {{tp|p=15606801|t=2005. Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus |pdf=|usr=}}{{15606801}} gab.com Text Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=15606801 #FOAvip T helper 1 driven immune responses facilitate host defence during viral infections. Because interleukin-18 (IL-18) mediates T helper 1 driven immune responses, and since mature IL-18 is up-regulated in human macrophages after influenza virus infection in vitro, it has been suggested that IL-18 plays an important role in the immune response to influenza. To determine the role of IL-18 in respiratory tract infection with influenza, IL-18 gene-deficient (IL-18?/?) and normal wildtype mice were intranasally inoculated with influenza A virus. Influenza resulted in an increase in constitutively expressed IL-18 in the lungs of wildtype mice. The clearance of influenza A was inhibited by IL-18, as indicated by reduced viral loads on day 8 and day 12 after infection in IL-18?/? mice. This enhanced viral clearance correlated with increased CD4+ T-cell activation in the lungs as reflected by CD69 expression on the cell surface. Surprisingly, interferon-? (IFN-?) levels were similar in the lungs of IL-18?/? mice and wildtype mice. Intracellular IFN-? staining revealed similar expression levels in lung-derived natural killer cells, CD4+ and CD8+ T cells, indicating that IFN-? production is IL-18-independent during influenza virus infection. Tumour necrosis factor-? production by CD4+ T cells was significantly lower in IL-18?/? mice than in wildtype mice. Our data indicate that endogenous IL-18 impairs viral clearance during influenza A infection. Twit Text FOAVip Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=15606801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15606801 #FOAvip English Wikipedia <ref>{{Cite pmid|15606801}}</ref> Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus #MMPMID15606801 Van Der Sluijs KF; Van Elden LJR; Arens R; Nijhuis M; Schuurman R; Florquin S; Kwakkel J; Akira S; Jansen HM; Lutter R; Van Der Polls T Immunology 2005[Jan]; 114 (1): 112-20 PMID15606801show ga T helper 1 driven immune responses facilitate host defence during viral infections. Because interleukin-18 (IL-18) mediates T helper 1 driven immune responses, and since mature IL-18 is up-regulated in human macrophages after influenza virus infection in vitro, it has been suggested that IL-18 plays an important role in the immune response to influenza. To determine the role of IL-18 in respiratory tract infection with influenza, IL-18 gene-deficient (IL-18?/?) and normal wildtype mice were intranasally inoculated with influenza A virus. Influenza resulted in an increase in constitutively expressed IL-18 in the lungs of wildtype mice. The clearance of influenza A was inhibited by IL-18, as indicated by reduced viral loads on day 8 and day 12 after infection in IL-18?/? mice. This enhanced viral clearance correlated with increased CD4+ T-cell activation in the lungs as reflected by CD69 expression on the cell surface. Surprisingly, interferon-? (IFN-?) levels were similar in the lungs of IL-18?/? mice and wildtype mice. Intracellular IFN-? staining revealed similar expression levels in lung-derived natural killer cells, CD4+ and CD8+ T cells, indicating that IFN-? production is IL-18-independent during influenza virus infection. Tumour necrosis factor-? production by CD4+ T cells was significantly lower in IL-18?/? mice than in wildtype mice. Our data indicate that endogenous IL-18 impairs viral clearance during influenza A infection. äEnhanced viral clearance in interleukin-18 gene-deficient mice after p(epmc).pdf DeepDyve Pubget Overpricing