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10.2353/ajpath.2006.050875 http://scihub22266oqcxt.onion/10.2353/ajpath.2006.050875 C1606556!1606556!16565492     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Pathol 2006 ; 168 (4): 1169-78 Nephropedia Template TP {{tp|p=16565492|t=2006. Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection |pdf=|usr=}}{{16565492}} gab.com Text Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=16565492 #FOAvip Respiratory infections, including influenza in humans, are often accompanied by a hepatitis that is usually mild and self-limiting. The mechanism of this kind of liver damage is not well understood. In the present study, we show that influenza-associated hepatitis occurs due to the formation of inflammatory foci that include apoptotic hepatocytes, antigen-specific CD8+ T cells, and Kupffer cells. Serum aminotransaminase levels were elevated, and both the histological and serum enzyme markers of hepatitis were increased in secondary influenza infection, consistent with a primary role for antigen-specific T cells in the pathogenesis. No virus could be detected in the liver, making this a pure example of ?collateral damage? of the liver. Notably, removal of the Kupffer cells prevented the hepatitis. Such hepatic collateral damage may be a general consequence of expanding CD8+ T-cell populations during many extrahepatic viral infections, yielding important implications for liver pathobiology. Twit Text FOAVip Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=16565492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16565492 #FOAvip English Wikipedia <ref>{{Cite pmid|16565492}}</ref> Kupffer Cell-Dependent Hepatitis Occurs during Influenza Infection #MMPMID16565492 Polakos NK; Cornejo JC; Murray DA; Wright KO; Treanor JJ; Crispe IN; Topham DJ; Pierce RH Am J Pathol 2006[Apr]; 168 (4): 1169-78 PMID16565492show ga Respiratory infections, including influenza in humans, are often accompanied by a hepatitis that is usually mild and self-limiting. The mechanism of this kind of liver damage is not well understood. In the present study, we show that influenza-associated hepatitis occurs due to the formation of inflammatory foci that include apoptotic hepatocytes, antigen-specific CD8+ T cells, and Kupffer cells. Serum aminotransaminase levels were elevated, and both the histological and serum enzyme markers of hepatitis were increased in secondary influenza infection, consistent with a primary role for antigen-specific T cells in the pathogenesis. No virus could be detected in the liver, making this a pure example of ?collateral damage? of the liver. Notably, removal of the Kupffer cells prevented the hepatitis. Such hepatic collateral damage may be a general consequence of expanding CD8+ T-cell populations during many extrahepatic viral infections, yielding important implications for liver pathobiology. äKupffer Cell-Dependent Hepatitis Occurs during Influenza Infection (epmc).pdf DeepDyve Pubget Overpricing