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suck abstract from ncbi


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pmid223977      Immunology 1979 ; 37 (2): 361-6
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  • Studies on the mechanism of macrophage aggregation induced by lymphokines #MMPMID223977
  • Badenoch-Jones P; Rouveix B; Turk JL
  • Immunology 1979[Jun]; 37 (2): 361-6 PMID223977show ga
  • Macrophage aggregation (measured by a light-scattering technique) induced by unpurified lymphokine preparations has been investigated. This has been shown to be Ca2+ or Mg2+ dependent and to be inhibited by a number of agents known to affect cellular physiology and biochemistry. The divalent cation ionophore A23187 causes a macrophage aggregation superficially similar to that induced by lymphokines, although differences were found. It is suggested that a biochemical response by the macrophage is required for aggregation induced by lymphokines, and thus measurements of macrophage aggregation allow a study of the early events in the response of macrophages to lymphokines.
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