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10.1128/JVI.76.12.6268-6276.2002 http://scihub22266oqcxt.onion/10.1128/JVI.76.12.6268-6276.2002 C136237!136237!12021360     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Virol 2002 ; 76 (12): 6268-76 Nephropedia Template TP {{tp|p=12021360|t=2002. 1-?-d-Arabinofuranosylcytosine Inhibits Borna Disease Virus Replication and Spread |pdf=|usr=}}{{12021360}} gab.com Text 1- -d-Arabinofuranosylcytosine Inhibits Borna Disease Virus Replication and Spread JO: J Virol http://www.kidney.de/pget.php?&tw=1&pmid=12021360 #FOAvip Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis. Although the clinical consequences of human BDV infection are still controversial, experimental BDV infection is a well-described model for human neuropsychiatric diseases. To date, there is no effective treatment against BDV. In this paper, we demonstrate that the nucleoside analog 1-?-d-arabinofuranosylcytosine (Ara-C), a known inhibitor of DNA polymerases, inhibits BDV replication. Ara-C treatment inhibited BDV RNA and protein synthesis and prevented BDV cell-to-cell spread in vitro. Replication of other negative-strand RNA viruses such as influenza virus or measles virus was not inhibited by Ara-C, underscoring the particularity of the replication machinery of BDV. Strikingly, Ara-C treatment induced nuclear retention of viral ribonucleoparticles. These findings could not be attributed to known effects of Ara-C on the host cell, suggesting that Ara-C directly inhibits the BDV polymerase. Finally, we show that Ara-C inhibits BDV replication in vivo in the brain of infected rats, preventing persistent infection of the central nervous system as well as the development of clinical disease. These findings open the way to the development of effective antiviral therapy against BDV. Twit Text FOAVip 1- -d-Arabinofuranosylcytosine Inhibits Borna Disease Virus Replication and Spread ????J Virol http://www.kidney.de/pget.php?&tw=1&pmid=12021360 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=12021360 #FOAvip English Wikipedia <ref>{{Cite pmid|12021360}}</ref> 1-?-d-Arabinofuranosylcytosine Inhibits Borna Disease Virus Replication and Spread #MMPMID12021360 Bajramovic JJ; Syan S; Brahic M; de la Torre JC; Gonzalez-Dunia D J Virol 2002[Jun]; 76 (12): 6268-76 PMID12021360show ga Borna disease virus (BDV) is a nonsegmented, negative-strand RNA virus that causes neurological diseases in a variety of warm-blooded animal species. There is general consensus that BDV can also infect humans, being a possible zoonosis. Although the clinical consequences of human BDV infection are still controversial, experimental BDV infection is a well-described model for human neuropsychiatric diseases. To date, there is no effective treatment against BDV. In this paper, we demonstrate that the nucleoside analog 1-?-d-arabinofuranosylcytosine (Ara-C), a known inhibitor of DNA polymerases, inhibits BDV replication. Ara-C treatment inhibited BDV RNA and protein synthesis and prevented BDV cell-to-cell spread in vitro. Replication of other negative-strand RNA viruses such as influenza virus or measles virus was not inhibited by Ara-C, underscoring the particularity of the replication machinery of BDV. Strikingly, Ara-C treatment induced nuclear retention of viral ribonucleoparticles. These findings could not be attributed to known effects of Ara-C on the host cell, suggesting that Ara-C directly inhibits the BDV polymerase. Finally, we show that Ara-C inhibits BDV replication in vivo in the brain of infected rats, preventing persistent infection of the central nervous system as well as the development of clinical disease. These findings open the way to the development of effective antiviral therapy against BDV. ä1-?-d-Arabinofuranosylcytosine Inhibits Borna Disease Virus Replicatio(epmc).pdf DeepDyve Pubget Overpricing