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1995 ; 88
(8
): 441-5
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Intracellular (polymorphonuclear) magnesium content in patients with bronchial
asthma between attacks
#MMPMID7562826
Fantidis P
; Ruiz Cacho J
; Marín M
; Madero Jarabo R
; Solera J
; Herrero E
J R Soc Med
1995[Aug]; 88
(8
): 441-5
PMID7562826
show ga
Previous studies have demonstrated the role of polymorphonuclears in asthma, the
importance of increases in intracellular concentrations of ionized calcium in the
release of chemical mediators, the role of magnesium as natural calcium channel
blocker, and the importance of magnesium deficiency in plasma histamine
concentration and in tissue prostanoid concentration. The objective of our study
was to measure the polymorphonuclear magnesium content in patients with asthma in
the interval between attacks. We measured the polymorphonuclear magnesium
content, and serum and erythrocyte sodium, calcium, and magnesium concentrations
in 21 healthy volunteers and 50 patients with different types of asthma. In our
patients, the polymorphonuclear magnesium content was lower than in the control
group (P < 0.001), while magnesium levels in erythrocytes and serum and the
levels of other ions in erythrocytes and serum were normal. This is the first
report to document low polymorphonuclear magnesium content in patients with
bronchial asthma. The reduction of polymorphonuclear magnesium content may have
an important role in the pathogenesis of asthma.