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10.1172/JCI25078 http://scihub22266oqcxt.onion/10.1172/JCI25078 C1288832!1288832 !16308574     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=16308574 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis |pdf=|usr=}}{{16308574 }} gab.com Text Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=16308574 #FOAvip The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the diversity and size of the memory CD8+ T cell population increase with age, we questioned whether IM was mediated by the reactivation of memory CD8+ T cells specific to previously encountered pathogens but cross-reactive with EBV. Of 8 HLA-A2+ IM patients, 5 had activated T cells specific to another common virus, as evidenced by a significantly higher number of peripheral blood influenza A virus M1(58-66)-specific T cells compared with healthy immune donors. Two patients with an augmented M1 response had tetramer-defined cross-reactive cells recognizing influenza M1 and EBV-BMLF1(280-288), which accounted for up to one-third of their BMLF1-specific population and likely contributed to a skewed M1-specific T cell receptor repertoire. These epitopes, with only 33% sequence similarity, mediated differential effects on the function of the cross-reactive T cells, which may contribute to alterations in disease outcome. EBV could potentially encode an extensive pool of T cell epitopes that activate other cross-reactive memory T cells. Our results support the concept that cross-reactive memory CD8+ T cells activated by EBV contribute to the characteristic lymphoproliferation of IM. Twit Text FOAVip Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=16308574 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16308574 #FOAvip English Wikipedia <ref>{{Cite pmid|16308574 }}</ref> Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis #MMPMID16308574 Clute SC ; Watkin LB ; Cornberg M ; Naumov YN ; Sullivan JL ; Luzuriaga K ; Welsh RM ; Selin LK J Clin Invest 2005[Dec]; 115 (12 ): 3602-12 PMID16308574 show ga The marked proliferation of activated CD8+ T cells is pathognomonic of EBV-associated infectious mononucleosis (IM), common in young adults. Since the diversity and size of the memory CD8+ T cell population increase with age, we questioned whether IM was mediated by the reactivation of memory CD8+ T cells specific to previously encountered pathogens but cross-reactive with EBV. Of 8 HLA-A2+ IM patients, 5 had activated T cells specific to another common virus, as evidenced by a significantly higher number of peripheral blood influenza A virus M1(58-66)-specific T cells compared with healthy immune donors. Two patients with an augmented M1 response had tetramer-defined cross-reactive cells recognizing influenza M1 and EBV-BMLF1(280-288), which accounted for up to one-third of their BMLF1-specific population and likely contributed to a skewed M1-specific T cell receptor repertoire. These epitopes, with only 33% sequence similarity, mediated differential effects on the function of the cross-reactive T cells, which may contribute to alterations in disease outcome. EBV could potentially encode an extensive pool of T cell epitopes that activate other cross-reactive memory T cells. Our results support the concept that cross-reactive memory CD8+ T cells activated by EBV contribute to the characteristic lymphoproliferation of IM. |Adolescent [MESH] |Adult [MESH] |CD8-Positive T-Lymphocytes/*cytology/immunology/metabolism/*virology [MESH] |Cell Proliferation [MESH] |Chemokine CCL4 [MESH] |Dose-Response Relationship, Drug [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Epitopes/chemistry [MESH] |Flow Cytometry [MESH] |Genes, MHC Class I [MESH] |HLA-A2 Antigen/chemistry [MESH] |Herpesvirus 4, Human/*metabolism [MESH] |Humans [MESH] |Immunologic Memory [MESH] |Infectious Mononucleosis/*virology [MESH] |Influenza A virus/immunology [MESH] |Interferon-gamma/metabolism [MESH] |K562 Cells [MESH] |Leukocytes, Mononuclear/cytology [MESH] |Lymphocyte Activation [MESH] |Lymphocytes/*cytology/*virology [MESH] |Macrophage Inflammatory Proteins/metabolism [MESH] |Orthomyxoviridae/*genetics [MESH] |Peptides/chemistry [MESH] |Receptors, Antigen, T-Cell/metabolism [MESH] |T-Lymphocytes/immunology/virology [MESH]Cross-reactive influenza virus-specific CD8+ T cells contribute to l(epmc).pdf DeepDyve Pubget Overpricing