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  • Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats #MMPMID12069992
  • Solbrig MV; Schlaberg R; Briese T; Horscroft N; Lipkin WI
  • Antimicrob Agents Chemother 2002[Jul]; 46 (7): 2287-91 PMID12069992garesp_yesshow ga
  • In a rat model of Borna disease, intracerebral ribavirin caused clinical improvement without changes in virus titer or nucleic acid. Levels of microglia and infiltrating CD4 and CD8 cells were decreased, despite increases in mRNAs encoding interleukin-1? (IL-1?), IL-10, and gamma interferon in the brain. Intracerebral ribavirin may reduce morbidity through effects on microglia cell proliferation.
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    2287 7.46 2002