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Phospholipid composition in small airway lining fluid among tunnel construction
workers exposed to respirable crystalline silica
#MMPMID41382182
Leite M
; Larsson P
; Kokelj S
; Nordby KC
; Alfonso JH
; Koca H
; Ulvestad B
; Ellingsen DG
; Olin AC
Lipids Health Dis
2025[Dec]; 24
(1
): 382
PMID41382182
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OBJECTIVE: To explore if the phospholipid composition in the small airway lining
fluid differed between a group of tunnel construction workers exposed to
respirable crystalline silica (RCS) and a reference group. METHODS: In total, 19
healthy, non-smoking workers under exposure to RCS and 21 unexposed referents
from the same construction site were included. The participants underwent a
health examination including lung function measurements and collection of exhaled
particles (PEx) using the Particles in exhaled air (PExA) method. Analysis of PEx
included determination of lipids. In total, 95 lipid species, primarily
phospholipids, were determined. Non-parametric analyses (Wilcoxon rank-sum test
and quantile regression), principal component analysis (PCA) and orthogonal
partial least squares discriminant analysis (OPLS-DA) were used for data
analysis. RESULTS: A difference in mol% of phospholipids between the RCS exposed
tunnel construction workers and unexposed referents was observed. On lipid class
level there was a higher mol% of sphingomyelin (SM) species among exposed workers
compared to referents. Regarding single phospholipid species, higher mol % of
phosphatidylcholine (PC) and phosphatidylglycerol (PG) species containing diacyl
chains with 18:2 (linoleic acid) and 20:4 (arachidonic acid) fatty acid
components were observed in the exposed group. Additionally, lower mol% of
saturated PC species were observed among the exposed. CONCLUSIONS: Differences in
phospholipid composition in the small airway lining fluid between workers exposed
to RCS and a reference group were observed. This indicates a possible impact of
RCS exposure on phospholipids in the small airways. However, whether these are
linked to health effects is currently not known.
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