Association Between Nucleated Red Blood Cell Counts and the Mortality in Patients
With Liver Diseases: An Analysis of the MIMIC-IV Database
#MMPMID41381803
Zhu Y
; Yan D
; Peng F
; Yao R
; Li N
J Cell Mol Med
2025[Dec]; 29
(23
): e70982
PMID41381803
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Liver disease is a leading cause of death worldwide. Nucleated red blood cells
(NRBCs) are associated with high mortality and poor outcomes in patients with
severe illnesses. However, the relationship between NRBCs and severe liver
disease remains unclear. Potential confounding effects were managed using
propensity score matching. The association between NRBCs and clinical outcomes in
patients with liver disease was clarified using Cox proportional hazards
regression analysis and smoothing splines. Differences in NRBCs between 30-day
survivors and non-survivors within the pre-matched cohort during the first
30?days after ICU admission were assessed using generalised additive mixed
models. Compared to the 30-day survivors, the 30-day non-survivors had
significantly higher NRBC counts. Higher NRBC counts were significantly
correlated with an augmented risk of 30-day, 90-day and in-hospital mortality,
with concurrently decreased hospitalisation durations. Inpatients with liver
disease, progressive increases in the 30-day mortality risk were associated with
increased NRBC counts. The association between NRBCs and enhanced 30-day
mortality rates was consistent across stages and etiologies. Moreover, 30-day
non-survivors experienced average daily increases in NRBC counts of 0.31%
compared with 30-day survivors. Elevated NRBC counts correlated with increased
30-, 90-day and in-hospital mortality in patients with liver disease.
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