Impact of Age, TNM Stage, and Hospitalization on Bladder Cancer Survival:
Evidence from a Hospital-Based Cohort in Eastern China
#MMPMID41384284
Lu LL
; Chen HZ
; Chen JG
Res Rep Urol
2025[]; 17
(?): 481-493
PMID41384284
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PURPOSE: To evaluate survival outcomes and identify prognostic factors among
bladder cancer patients. PATIENTS AND METHODS: A total of 488 bladder cancer
patients admitted between 2007 and 2017 were followed until December 31, 2020,
using both active and passive follow-up. The Kaplan-Meier method was used to
estimate observed survival (OS), with group comparisons performed using the Log
rank test. Variables included sex, age group, number of hospital admissions, TNM
stage, and geographic origin. RESULTS: Of 488 patients, 485 (99.38%) were
successfully followed. The majority were male (80.21%) with a mean age of 66.5
years. The average number of hospital admissions was 1.81. Overall 1-, 3-, 5-,
and 10-year OS rates were 79.95%, 63.50%, 56.32%, and 45.54% for males, and
69.79%, 58.33%, 56.01%, and 56.01% for females, respectively (P = 0.697). Age
significantly affected prognosis (P < 0.01), with 5-year OS declining from 66.67%
(age ?34) to 29.53% (?80). Patients with ?3 admissions had worse survival
(44.87%) than those with one (61.93%) or two admissions (58.97%) (P < 0.01). TNM
stage was strongly with survival: 5-year OS rates were 86.43% (Stage I), 55.48%
(Stage II), 38.25% (Stage III), and 13.85% (Stage IV) (P < 0.01). Regional
differences were not statistically significant (P > 0.05). CONCLUSION: Advanced
age and late-stage diagnosis were associated with poorer survival, while
early-stage detection correlated with better outcomes. These findings underscore
the importance of early screening, timely treatment, and comprehensive care
strategies to improve bladder cancer survival, especially in resource-limited
settings. Limitations include single-center design and absence of multivariate
adjustment.
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