Doxorubicin drug delivery using an electrospun nanofiber membrane of
chitosan-polycaprolactone with metal-organic framework: Box-Behnken optimization,
anticancer treatment, and antimicrobial activity
#MMPMID41384078
Alotaibi FT
; Alamri MA
; Alneghery LM
; Alaseem AM
; El-Desouky MG
; El-Bindary AA
RSC Adv
2025[Dec]; 15
(57
): 49243-49268
PMID41384078
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Metal-organic frameworks (MOFs) have become significant nanocarriers for drug
delivery owing to their remarkable high surface area, adjustable porosity, and
functional adaptability. This research focused on developing a multifunctional
pH-responsive delivery system by encapsulating doxorubicin (DOX) within a
lanthanum-based MOF (La-MOF) and integrating this complex into a biocompatible
electrospun nanofiber membrane made of polycaprolactone (PCL) and chitosan (CS).
The resulting DOX@La-MOF/CS-PCL nanofiber membrane was created by means of a
one-step electrospinning technique and extensively analyzed using XRD, FTIR, XPS,
SEM, EDX, and BET techniques to confirm its structural honesty, surface
morphology, and chemical makeup. Drug release experiments indicated a
dual-responsive behavior, demonstrating much higher DOX release at body
temperature (37 °C) and in acidic environment (pH 5.0) that mimic the tumor micro
environment. According to kinetic analysis, diffusion and erosion worked together
to affect the release mechanism, which is consistent with zero-order,
first-order, Korsmeyer-Peppas, as well as Higuchi models. In vitro tests
exhibited strong anticancer effects against liver (HepG2), breast (MCF-7), and
skin (A-431) lines of cancer cells. In addition to significant antioxidant and
antimicrobial achievement in contrast to Staphylococcus aureus, Escherichia coli,
as well as Candida albicans. Further optimization through a Box-Behnken
statistical design improved both drug loading and release efficiency. Overall,
these findings high spot the potential of the DOX@La-MOF/CS-PCL nanofiber
membrane as a versatile and effective platform for controlled drug delivery,
cancer treatment, and various biomedical applications.
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