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Lifetime Cannabis, Non-Cigarette Tobacco, and Illicit Drug Use and Cardiovascular
Disease Among Young and Middle-Aged U S Adults
#MMPMID41384047
Agbonlahor O
; Mattingly DT
; Hart JL
; Richardson MK
; McLeish AC
; Walker KL
Am J Lifestyle Med
2025[Dec]; ? (?): 15598276251404883
PMID41384047
show ga
Background: Despite increases in cardiovascular disease (CVD) prevalence among
young and middle-aged adults in the United States (U.S.), associations between
lifetime use of cannabis, non-cigarette tobacco products, and illicit drugs with
CVD are not fully known. This study aimed to examine these associations among
young and middle-aged U.S. adults. Methods: We analyzed a sample of 2933 adults
aged 20-59 years from the National Health and Nutrition Examination Survey
(2017-2018). CVD (i.e., health care provider diagnosis of coronary heart disease,
stroke, or high blood pressure), and substance use (i.e., ever use of cannabis,
non-cigarette tobacco, or illicit drugs) were assessed. Adjusted odds ratios were
estimated using multivariable logistic regression. Results: Adults who used
cannabis had higher odds of coronary heart disease (OR = 5.45, 95% CI:
1.86-15.95), and adults who used cigars had higher odds of stroke (OR = 2.31, 95%
CI: 1.06-5.01). Further, increased odds of high blood pressure were associated
with e-cigarette (OR = 1.41, 95% CI: 1.12-1.79) and smokeless tobacco (OR = 1.46,
95% CI: 1.01-2.12) use. Conclusions: Lifetime cannabis and non-cigarette use was
associated with CVD among young and middle-aged U.S. adults, with the spectrum of
disease varying based on substance type. CVD prevention should involve
non-cigarette tobacco and cannabis use screening and counseling.
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