The relation between postoperative cognitive disorders and brain damage
biomarkers after major urologic surgery: a prospective cohort study
#MMPMID41345719
?entürk E
; Sungur Z
; ?entürk Çiftçi H
; K?k?l? M?
; ?anl? MÖ
; K?vanç D
; Bingül ES
; Canbaz M
; Ergül RB
; Savran Karadeniz M
Perioper Med (Lond)
2025[Oct]; 14
(1
): 116
PMID41345719
show ga
BACKGROUND: Postoperative neurocognitive disorders (PNDs) are highly prevalent
among the elderly population. Identifying an ideal biomarker for postoperative
delirium (POD) and postoperative cognitive dysfunction (POCD) remains a
significant challenge. This study aimed to investigate the relationship between
these syndromes and various biomarkers, including S-100?, neuron-specific enolase
(NSE), interleukin-6 (IL-6), and high-mobility group box-1 (HMGB-1). METHODS: The
study included patients aged 60 years and older who underwent surgery for primary
urologic malignancies. POD was evaluated in the recovery room using the Confusion
Assessment Method (CAM). POCD was assessed preoperatively and at the first week
(POCD1) and third month (POCD3) postoperatively using Addenbrooke's Cognitive
Examination-III (ACE-III). Biomarker levels of S-100?, neuron-specific enolase
(NSE), interleukin-6 (IL-6), and high-mobility group box-1 (HMGB-1) were measured
using enzyme-linked immunosorbent assay (ELISA). RESULTS: A total of 54 patients
completed the study. POD was diagnosed in 12 patients (22.2%), while POCD1 and
POCD3 were identified in 17 (31.5%) patients and 12 (22.2%) patients
respectively. The mean age of the participants was 73.8?±?7.1 years. Preoperative
levels of NSE were significantly higher in patients with POD compared to those
without (p?=?0.04). Additionally, preoperative and postoperative IL-6 levels, as
well as preoperative and postoperative S-100? levels, were significantly elevated
in patients with POCD1 compared to those without (p?
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