Synergizing biomaterials and cellular molecular pathways: a new frontier in hair
follicle generation
#MMPMID41345670
Bajouri A
; Aghdami N
; Nilforoushzadeh MA
J Transl Med
2025[Oct]; 23
(1
): 1170
PMID41345670
show ga
Despite significant advances in our understanding of hair follicle cycling and
regeneration, creating fully functional hair follicles with active cycling
capabilities remains a considerable challenge for clinical applications. This
literature review aims to explore the molecular and cellular mechanisms that
govern hair follicle development and cycling, highlighting key signaling pathways
involved in these processes. We also discuss biomaterials and emerging
regenerative strategies that show promise for biofabricating hair follicles.
Specifically, we summarize current research on innovative techniques such as hair
micropatterning models, hair follicle organoids, three-dimensional printing of
microneedle arrays, microfollicle generation, and biofabrication technologies.
This review emphasizes the necessity of a multifaceted approach that integrates
stem cell research and tissue engineering technologies to optimize hair follicle
regeneration and enhance therapeutic outcomes.
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