Advanced multifunctional nano-delivery platform focusing on treating diseases
related to lipid metabolism via targeted intervention in various lipid metabolic
processes
#MMPMID41345744
Sun Y
; Yan K
; Zhang Y
; Han YQ
; Hao LH
; Gao Y
; Wang HL
; Chu HQ
; Ye J
; Liu YL
; Yang YF
Mil Med Res
2025[Dec]; 12
(1
): 87
PMID41345744
show ga
Disruptions in lipid metabolism cause numerous metabolic diseases, including
obesity, diabetes, cardiovascular diseases, and liver disorders. Consequently,
lipid metabolism serves as a potential therapeutic target, influencing the
progression of various non-metabolic diseases such as kidney diseases, cancer,
neurodegenerative disorders, aging, and bone-related diseases. The metabolic
pathways involved in lipid metabolism are complex and highly interconnected.
Although the abundance of metabolic targets presents opportunities for lipid
metabolism regulation, the limited precision and safety of traditional
therapeutic approaches remain significant challenges. These limitations have
catalyzed the development of multifunctional nano-delivery platforms aimed at
targeted intervention in lipid metabolic processes, further enhancing the
flexibility of lipid metabolism regulation. This review outlines the latest
advancements and representative applications of these multifunctional
nano-delivery platforms. Notably, extensive research has been conducted on
nanoparticles and liposomes, with these technologies being relatively mature.
Furthermore, numerous novel biomaterials, including engineered adipocytes,
exosome vesicles secreted by natural cells, smart-responsive nanomicelles,
composite hydrogels, and engineered lipid droplets, are being increasingly
explored. Finally, the review discusses the advantages of drug delivery
strategies based on the targeted intervention of lipid metabolic processes, the
limitations of current technologies, promising future research directions, and
treatment challenges.
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