Declining incidence but little change in years lived with dementia in two German
cohorts diagnosed with dementia in 2006/2008 and 2016/2018
#MMPMID41331692
Doblhammer G
; Erlangsen A
; Fink A
; Canudas-Romo V
Alzheimers Res Ther
2025[Dec]; 17
(1
): 255
PMID41331692
show ga
BACKGROUND: We examined whether changes in dementia incidence and mortality have
led to changes in the average number of years lived with and without dementia
over a ten-year period in Germany. METHODS: We calculated dementia rates using
two samples of people aged 65?+?from a German health insurance company, each
comprising more than 100,000 people in 2006/08 and 2016/18. We examined time
trends using negative binomial regression models and estimated average life
expectancy (ALE) for people with and without dementia by fitting a three-stage
Markov health-disease model. RESULTS: Dementia incidence rates decreased by 7.3%
in men and by 9.7% in women. Dementia mortality rates fell by 12% in men but did
not change significantly in women. Non-dementia mortality rates fell by 7% in
both men and women. The combined changes resulted in stable total ALE in men and
increasing total ALE in women, whereas ALE with dementia increased in men and
remained stable in women. CONCLUSIONS: The observed decline in dementia incidence
did not translate into a reduction in the burden of the disease. SUPPLEMENTARY
INFORMATION: The online version contains supplementary material available at
10.1186/s13195-025-01911-7.
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