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10.1186/s12871-025-03462-8 http://scihub22266oqcxt.onion/10.1186/s12871-025-03462-8 C12625608!12625608 !41254500     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41254500 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       BMC+Anesthesiol 2025 ; 25 (1 ): 571 Nephropedia Template TP {{tp|p=41254500 |t=2025. The effective dose of remimazolam in combination with sufentanil for sedation during transvaginal oocyte retrieval: an up-and-down sequential allocation trial |pdf=|usr=}}{{41254500 }} gab.com Text The effective dose of remimazolam in combination with sufentanil for sedation during transvaginal oocyte retrieval: an up-and-down sequential allocation trial JO: BMC Anesthesiol http://www.kidney.de/pget.php?&tw=1&pmid=41254500 #FOAvip BACKGROUND: The potential adverse effects of propofol on fertilization outcomes have raised concerns among patients undergoing anesthesia for oocyte retrieval. Remimazolam is a new type of ultra-short-acting benzodiazepine. This study aimed to find the effective dose of remimazolam in combination with sufentanil for sedation in oocyte retrieval. METHODS: Patients aged 20 to 45 years with a BMI of 18.5 to 27.9 kg/m² and ASA physical status I or II, undergoing transvaginal oocyte retrieval, were recruited. All patients were administered intravenous sufentanil at a dose of 0.1 µg/kg, followed by intravenous remimazolam after 2 min. The initial remimazolam dose was set at 0.2 mg/kg and adjusted by 0.02 mg/kg according to the modified Dixon sequential method. The primary endpoint was successful sedation, defined as a Modified Observer?s Assessment of Alertness/Sedation (MOAA/S) score???1 and an Intraoperative Movement Scale (IOMS) score?<?2 within 5 min. Adverse events were recorded. The estimation of ED(50), ED(90) and ED(95) with a 95% confidence interval (CI) was conducted by probit regression. RESULTS: The ED(50), ED(90) and ED(95) of remimazolam for successful sedation in combination with sufentanil induction were 0.205 mg/kg (95% CI 0.190?0.222), 0.232 mg/kg (95% CI 0.218?0.311) and 0.240 mg/kg (95% CI 0.223?0.339), respectively. There were three cases of hypoxemia, with no other adverse events reported, including injection pain, hypotension, bradycardia, dizziness, nausea, vomiting, or delayed emergence. CONCLUSIONS: In summary, when combined with 0.1 µg/kg of sufentanil, the ED(50), ED(90) and ED(95) values of remimazolam for effective sedation during transvaginal oocyte retrieval, were 0.205 mg/kg, 0.232 mg/kg and 0.240 mg/kg, respectively, with a low occurrence of adverse events. TRIAL REGISTRATION: The study protocol was registered at http://www.chictr.org.cn (registration number: ChiCTR2400082576 on 01/04/2024). Twit Text FOAVip The effective dose of remimazolam in combination with sufentanil for sedation during transvaginal oocyte retrieval: an up-and-down sequential allocation trial ????BMC Anesthesiol http://www.kidney.de/pget.php?&tw=1&pmid=41254500 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41254500 #FOAvip English Wikipedia <ref>{{Cite pmid|41254500 }}</ref> The effective dose of remimazolam in combination with sufentanil for sedation during transvaginal oocyte retrieval: an up-and-down sequential allocation trial #MMPMID41254500 Lu Y ; Duan G ; Fu J ; Luo F ; Wang B ; Lang J BMC Anesthesiol 2025[Nov]; 25 (1 ): 571 PMID41254500 show ga BACKGROUND: The potential adverse effects of propofol on fertilization outcomes have raised concerns among patients undergoing anesthesia for oocyte retrieval. Remimazolam is a new type of ultra-short-acting benzodiazepine. This study aimed to find the effective dose of remimazolam in combination with sufentanil for sedation in oocyte retrieval. METHODS: Patients aged 20 to 45 years with a BMI of 18.5 to 27.9 kg/m² and ASA physical status I or II, undergoing transvaginal oocyte retrieval, were recruited. All patients were administered intravenous sufentanil at a dose of 0.1 µg/kg, followed by intravenous remimazolam after 2 min. The initial remimazolam dose was set at 0.2 mg/kg and adjusted by 0.02 mg/kg according to the modified Dixon sequential method. The primary endpoint was successful sedation, defined as a Modified Observer?s Assessment of Alertness/Sedation (MOAA/S) score???1 and an Intraoperative Movement Scale (IOMS) score? ?The effective dose of remimazolam in combination with sufentanil for s(epmc).pdf DeepDyve Pubget Overpricing