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2025 ; 20
(1
): 122
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Inflammatory fibroid polyps of the colon: a study on the morphological spectrum,
immunoexpression characteristics, and outcomes
#MMPMID41131517
Changfei Q
; Tingzhen Z
; Xiangling L
; Dingzhun L
; Zhang W
Diagn Pathol
2025[Oct]; 20
(1
): 122
PMID41131517
show ga
BACKGROUND: Colonic inflammatory fibroid polyps (IFPs) have not been extensively
studied. METHODS: In this study, we collected nine cases of colonic IFPs and
provide a comprehensive description of the clinicopathological features and
developmental outcomes of these lesions. RESULTS: These nine cases of colonic
IFPs can be classified into four types on the basis of their pathological
characteristics: early-stage, classic, inflammatory, and sclerotic. The
early-stage type of IFP is characterized by the deposition of fibrosis around
blood vessels and between glands. The classic type of IFP is easily identifiable
by its ?onion-skin-like? structure; however, immunohistochemical (IHC) staining
for CD34 may demonstrate focal positivity or even negativity. The inflammatory
type of IFP is large and characterized by significant infiltration of plasma
cells. IHC staining revealed variable positivity for both CD34 and PDGFR? across
different regions of the lesions. The sclerotic type of IFP is characterized by
substantial deposition of collagen. Furthermore, our findings suggest that
early-stage IFPs have the potential to either develop into classic-type IFPs or
degenerate into sclerotic-type IFPs. Additionally, classic-type IFPs may acquire
PDGFR? mutations and ultimately transform into inflammatory-type IFPs.
CONCLUSIONS: Colonic IFPs exhibit a distinct morphological spectrum and unique
immunoexpression characteristics as they progress. Only inflammatory-type and
classic-type IFPs with PDGFR? mutations or immunoexpression should be regarded as
genuine neoplastic lesions.