Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12711-025-01010-z http://scihub22266oqcxt.onion/10.1186/s12711-025-01010-z C12551222!12551222 !41131451     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41131451 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131451 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genet+Sel+Evol 2025 ; 57 (1 ): 58 Nephropedia Template TP {{tp|p=41131451 |t=2025. The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed |pdf=|usr=}}{{41131451 }} gab.com Text The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed JO: Genet Sel Evol http://www.kidney.de/pget.php?&tw=1&pmid=41131451 #FOAvip BACKGROUND: The historical importation of Chinese pigs into Western countries has facilitated the introduction of Chinese haplotypes into European pig breeds, thereby shaping their genetic diversity and phenotypic traits. However, the genetic and biological implications of this introgression remain poorly understood. RESULTS: Based on SNP chip and resequencing data, we confirmed significant genetic introgression from Chinese pigs into commercial European lines. The genetic origins of the introgressed segments predominantly derive from Southern Chinese domestic pigs (CSDP), with additional contributions from other populations, such as Eastern Chinese domestic pigs (CEDP). Our study demonstrates that the selection pressure for Chinese pig introgression was stronger in Duroc pigs compared to the Large White and Landrace breeds. Based on ancestral haplotypes from CEDP and CSDP, we conducted a genome-wide association study (GWAS) and identified 10 quantitative trait loci (QTLs), five of which were not identified in previous studies or using SNPs. Expression genome-wide association studies (eGWAS) based on these introgressed haplotypes, using gene expression profiles from the duodenum, liver, and muscle tissues in the Duroc population, revealed eGWAS signals that were enriched near transcript start sites. By integrating GWAS signals for loin muscle depth with eGWAS signals in muscle tissue, we confirmed that a region 300 Kb from TAF11, which is enriched with open chromatin regions and encompasses a super-enhancer located within the same topologically associating domain as TAF11, was associated with both TAF11 expression and loin muscle depth, highlighting the profound influence of Chinese introgression. CONCLUSIONS: These findings offer valuable insights into the genetic influences of Chinese pig introgression on the Duroc breed, as well as the molecular basis for its effects on economically important traits in Duroc pigs. Twit Text FOAVip The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed ????Genet Sel Evol http://www.kidney.de/pget.php?&tw=1&pmid=41131451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131451 #FOAvip English Wikipedia <ref>{{Cite pmid|41131451 }}</ref> The impact of haplotypes derived from Chinese pigs on genetic variation and economic traits in the Duroc breed #MMPMID41131451 Fang S ; Guo C ; Liu H ; Wang Y ; Tan C ; Wu Z ; Zhao Y ; Hu X ; Yang R Genet Sel Evol 2025[Oct]; 57 (1 ): 58 PMID41131451 show ga BACKGROUND: The historical importation of Chinese pigs into Western countries has facilitated the introduction of Chinese haplotypes into European pig breeds, thereby shaping their genetic diversity and phenotypic traits. However, the genetic and biological implications of this introgression remain poorly understood. RESULTS: Based on SNP chip and resequencing data, we confirmed significant genetic introgression from Chinese pigs into commercial European lines. The genetic origins of the introgressed segments predominantly derive from Southern Chinese domestic pigs (CSDP), with additional contributions from other populations, such as Eastern Chinese domestic pigs (CEDP). Our study demonstrates that the selection pressure for Chinese pig introgression was stronger in Duroc pigs compared to the Large White and Landrace breeds. Based on ancestral haplotypes from CEDP and CSDP, we conducted a genome-wide association study (GWAS) and identified 10 quantitative trait loci (QTLs), five of which were not identified in previous studies or using SNPs. Expression genome-wide association studies (eGWAS) based on these introgressed haplotypes, using gene expression profiles from the duodenum, liver, and muscle tissues in the Duroc population, revealed eGWAS signals that were enriched near transcript start sites. By integrating GWAS signals for loin muscle depth with eGWAS signals in muscle tissue, we confirmed that a region 300 Kb from TAF11, which is enriched with open chromatin regions and encompasses a super-enhancer located within the same topologically associating domain as TAF11, was associated with both TAF11 expression and loin muscle depth, highlighting the profound influence of Chinese introgression. CONCLUSIONS: These findings offer valuable insights into the genetic influences of Chinese pig introgression on the Duroc breed, as well as the molecular basis for its effects on economically important traits in Duroc pigs. |*Genetic Variation [MESH] |*Haplotypes [MESH] |*Sus scrofa/genetics [MESH] |Animals [MESH] |Breeding [MESH] |China [MESH] |Genetic Introgression [MESH] |Genome-Wide Association Study [MESH] |Phenotype [MESH] |Polymorphism, Single Nucleotide [MESH] |Quantitative Trait Loci [MESH]The impact of haplotypes derived from Chinese pigs on genetic variatio(epmc).pdf DeepDyve Pubget Overpricing