Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131458
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Gastroenterol
2025 ; 25
(1
): 753
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Association of gastroesophageal reflux disease with small intestinal bacterial
overgrowth: a case-control study
#MMPMID41131458
Hu Z
; Shan B
; Wang Y
; Yang J
; Lu L
; Wang Y
; Pang X
BMC Gastroenterol
2025[Oct]; 25
(1
): 753
PMID41131458
show ga
OBJECTIVE: To explore the potential correlation between alterations in gut
microbiota and gastroesophageal reflux disease (GERD) among patients. METHODS: A
case-control study was conducted, involving 50 patients diagnosed with GERD
through esophageal pressure measurement and 24-hour dynamic gastric acid
monitoring, as well as 53 symptom-matched controls (SCG). All participants
underwent Gastrointestinal Symptom Rating Scale (GSRS), Generalized Anxiety
Disorder 7-item scale (GAD-7), and Pittsburgh Sleep Quality Index (PSQI)
assessments. Methane (CH(4)) and hydrogen (H(2)) breath tests were conducted to
collect essential clinical data for both groups. Finally, the relationship
between small intestinal bacterial overgrowth (SIBO) and GERD was analyzed using
Spearman correlation analysis. RESULTS: In the GERD group, GSRS, anxiety rate,
and PSQI were all increased (p?0.001). The positive rate of SIBO in the GERD
group is significantly higher than that in the SCG group (p?0.05). The mean
expiratory H(2) abundance was significantly higher in the GERD group than in the
SCG group. SIBO is positively correlated with GERD and GSRS, and positively
correlated with sleep quality and anxiety. GERD is positively correlated with
GSRS, and positively correlated with sleep quality and anxiety. CONCLUSION: The
mean expiratory H(2) abundance was significantly higher in the GERD group. There
may be a potential connection between SIBO and the occurrence of GERD. And SIBO
may provide a new perspective on the pathogenesis of GERD. SUPPLEMENTARY
INFORMATION: The online version contains supplementary material available at
10.1186/s12876-025-04291-2.