Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12883-025-04477-x http://scihub22266oqcxt.onion/10.1186/s12883-025-04477-x C12551158!12551158 !41131511     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131511 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Neurol 2025 ; 25 (1 ): 437 Nephropedia Template TP {{tp|p=41131511 |t=2025. Identification of exosome-related gene biomarkers for parkinson s disease: a multi-omics approach for early diagnosis and therapeutic targeting |pdf=|usr=}}{{41131511 }} gab.com Text Identification of exosome-related gene biomarkers for parkinson s disease: a multi-omics approach for early diagnosis and therapeutic targeting JO: BMC Neurol http://www.kidney.de/pget.php?&tw=1&pmid=41131511 #FOAvip Parkinson?s disease (PD) is a neurodegenerative disorder linked to alpha-synuclein pathology and dopaminergic neuron loss. Exosomes play dual roles in PD progression, facilitating pathological protein spread or exerting neuroprotective effects. This study aimed to identify exosome-related gene biomarkers for PD diagnosis and therapy. Using multi-dataset analysis (Series: GSE42966, Platforms: GPL4133, Series: GSE99039, Platforms: GPL570, Series: GSE156926, Platforms: GPL19920) from the Gene Expression Omnibus (GEO), we integrated principal component analysis (PCA), differential gene screening (|logFC|>0.5, p?<?0.05), and machine learning to identify PD-associated exosome-related genes. Functional enrichment revealed associations with oxidative phosphorylation, Huntington?s disease pathways, and immune responses. A predictive model comprising five genes?GNAS, TUBB2A, RPL22, RPL5, and WNT5A?was established and validated using ROC curves (Receiver Operating Characteristic Curve) and nomograms. Immune profiling linked these genes to B cells, MDSCs, and CD4+/CD8?+?T cells. Drug-gene network analysis highlighted interactions with compounds like NSC94017 and phosphine, while molecular docking identified key binding residues (e.g., GLN294, ASP295). These genes may serve as early diagnostic biomarkers and therapeutic targets. Despite promising results, further validation in larger cohorts and mechanistic studies are needed to confirm their roles in PD pathogenesis and treatment. This study provides a foundation for developing precision gene therapies and non-invasive diagnostic strategies for PD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-025-04477-x. Twit Text FOAVip Identification of exosome-related gene biomarkers for parkinson s disease: a multi-omics approach for early diagnosis and therapeutic targeting ????BMC Neurol http://www.kidney.de/pget.php?&tw=1&pmid=41131511 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131511 #FOAvip English Wikipedia <ref>{{Cite pmid|41131511 }}</ref> Identification of exosome-related gene biomarkers for parkinson s disease: a multi-omics approach for early diagnosis and therapeutic targeting #MMPMID41131511 Chen S ; Feng N ; Liu Y BMC Neurol 2025[Oct]; 25 (1 ): 437 PMID41131511 show ga Parkinson?s disease (PD) is a neurodegenerative disorder linked to alpha-synuclein pathology and dopaminergic neuron loss. Exosomes play dual roles in PD progression, facilitating pathological protein spread or exerting neuroprotective effects. This study aimed to identify exosome-related gene biomarkers for PD diagnosis and therapy. Using multi-dataset analysis (Series: GSE42966, Platforms: GPL4133, Series: GSE99039, Platforms: GPL570, Series: GSE156926, Platforms: GPL19920) from the Gene Expression Omnibus (GEO), we integrated principal component analysis (PCA), differential gene screening (|logFC|>0.5, p? äIdentification of exosome-related gene biomarkers for parkinson s dise(epmc).pdf DeepDyve Pubget Overpricing