Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41746-025-01997-1 http://scihub22266oqcxt.onion/10.1038/s41746-025-01997-1 C12550013!12550013 !41131344     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131344 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       NPJ+Digit+Med 2025 ; 8 (1 ): 623 Nephropedia Template TP {{tp|p=41131344 |t=2025. Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets |pdf=|usr=}}{{41131344 }} gab.com Text Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets JO: NPJ Digit Med http://www.kidney.de/pget.php?&tw=1&pmid=41131344 #FOAvip Rheumatoid arthritis (RA) is a heterogeneous disease with variable symptoms, prognosis, and treatment response, necessitating refined patient classification. We applied multimodal deep learning and clustering to identify distinct RA phenotypes using baseline clinical data from 1,387 patients in the Leiden Rheumatology clinic. Four Joint Involvement Patterns (JIP) emerged: foot-predominant arthritis, seropositive oligoarticular disease, seronegative hand arthritis, and polyarthritis. Findings were validated in clinical trial data (n?=?307) and an independent secondary care cohort (n?=?515). Clusters showed high stability and significant differences in remission rates (P?=?0.007) and methotrexate failure (P?<?0.001). JIP-hand patients had superior outcomes (particularly in ACPA-positive patients) versus JIP-foot (HR:0.37, P?<?0.001) and JIP-poly (HR:0.33, P?=?0.005), independent of baseline disease activity and clinical markers. Synovial histology analysis (n?=?194) revealed distinct inflammatory patterns across clusters, hinting at different underlying biological mechanisms. These validated RA phenotypes based on joint involvement patterns may enable targeted research into disease mechanisms and personalized treatment strategies. Twit Text FOAVip Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets ????NPJ Digit Med http://www.kidney.de/pget.php?&tw=1&pmid=41131344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131344 #FOAvip English Wikipedia <ref>{{Cite pmid|41131344 }}</ref> Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets #MMPMID41131344 Maarseveen TD ; Maurits MP ; Coletto LA ; Perniola S ; Böhringer S ; Steinz N ; Bergstra SA ; Bruno D ; Gigante MR ; Pacucci VA ; Petricca L ; Boxma-de Klerk B ; Glas HK ; Di Mario C ; Campobasso D ; Tolusso B ; Veris-van Dieren J ; van der Helm-van Mil AHM ; Gremese E ; D'Agostino MA ; Reinders MJT ; Gessi M ; Huizinga TWJ ; Alivernini S ; van den Akker EB ; Knevel R NPJ Digit Med 2025[Oct]; 8 (1 ): 623 PMID41131344 show ga Rheumatoid arthritis (RA) is a heterogeneous disease with variable symptoms, prognosis, and treatment response, necessitating refined patient classification. We applied multimodal deep learning and clustering to identify distinct RA phenotypes using baseline clinical data from 1,387 patients in the Leiden Rheumatology clinic. Four Joint Involvement Patterns (JIP) emerged: foot-predominant arthritis, seropositive oligoarticular disease, seronegative hand arthritis, and polyarthritis. Findings were validated in clinical trial data (n?=?307) and an independent secondary care cohort (n?=?515). Clusters showed high stability and significant differences in remission rates (P?=?0.007) and methotrexate failure (P? äLocation and amount of joint involvement differentiates rheumatoid art(epmc).pdf DeepDyve Pubget Overpricing