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2025 ; 25
(1
): 1398
Nephropedia Template TP
gab.com Text
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English Wikipedia
Care at home for remdesivir treatment of COVID-19: a survey study of patient and
physician experiences
#MMPMID41131504
Nguyen J
; Hechter R
; Ling-Grant D
; Yao J
; Portugal C
; Bai A
; Calderon R
; Towner W
BMC Infect Dis
2025[Oct]; 25
(1
): 1398
PMID41131504
show ga
BACKGROUND: During the COVID-19 pandemic, remdesivir (RDV) treatment and advanced
medical care at home (AMCAH) were pivotal implementations for delivery of
comprehensive outpatient services. METHODS: A retrospective survey study was
conducted to assess patient and physician experiences of RDV treatment. The
online/telephone survey questionnaire was developed based on components of the
Health Belief Model, Hospital Consumer Assessment of Healthcare Providers
(HCAHPS), and physician change management theory. Patients???18 years of age
(N?=?1681) who received a three- or five-day RDV treatment regimen at home and
prescribing physicians (N?=?406) from December 15, 2020-August 31, 2022, in a
large integrated non-profit health system were eligible. A cross-sectional
analysis was performed to assess the associations of perceptions about value with
patient adherence to 100% of prescribed doses, physician adoption of treatment
guidelines, and patients? healthcare utilization. Reduction in COVID-19 related
readmission within 30 days of entry into treatment program was also measured.
Descriptive statistics were used to describe categorical responses. RESULTS: Of
survey results from 539 patient respondents (response rate: 32%, mean age: 58.4
years (SD 16.2), 55.1% male), race/ethnicity was predominantly Hispanic (48.4%),
followed by White (32.3%), and Black (12.6%). Adherence was 87% of patients
having completed 100% of RDV doses at home. Patients (79.9%) reporting being
?very satisfied? with medical follow-up were less frequently readmitted within 30
days (p?0.01). Of 140 physician respondents (response rate: 34%, mean age: 46.9
years (SD 8.4), 58% male), race/ethnicity was predominantly Asian (66%), followed
by White (23%), and Hispanic (7.1%). Prescribing was associated with feeling
knowledgeable about RDV (p?0.01) and perceived effectiveness for reducing
community transmission (p?=?0.03). CONCLUSIONS: In racially diverse samples,
patients and physicians responded favorably towards AMCAH integrating RDV for
treatment of COVID-19. Easy to understand communication and hospital readmission
were found to most shape patient satisfaction. AMCAH during the pandemic
demonstrated that acute care needs of patients can be safely met at home. These
findings inform future design of health care delivery and support expansion for
treatment of other acute illnesses. KEY POINTS: QUESTION: What were patient and
physician responses to advanced medical care at home integrating RDV for
treatment of COVID-19? FINDINGS: In this survey study, majority of eligible
patients (87%) completed 100% home RDV. Patients reported physicians most
influenced their decision to accept treatment (70.7%) and high satisfaction with
telehealth (95.8%). Patients who reported being ?very satisfied? with medical
follow-up (81.8%) were less frequently readmitted within 30 days (p<0.01).
Physician prescribing of RDV was associated with knowledge (p<0.01) and perceived
effectiveness for reducing community transmission (p=0.03). Most physicians
reported confidence in nurse capacity (88.2%) and pharmacy services (96.3%) to
support care at home. SUPPLEMENTARY INFORMATION: The online version contains
supplementary material available at 10.1186/s12879-025-11737-1.