Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12879-025-11656-1 http://scihub22266oqcxt.onion/10.1186/s12879-025-11656-1 C12548242!12548242 !41131459     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131459 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Infect+Dis 2025 ; 25 (1 ): 1393 Nephropedia Template TP {{tp|p=41131459 |t=2025. Pre-treatment and acquired HIV drug resistance in Hunan: a cross-sectional analysis of a growing challenge |pdf=|usr=}}{{41131459 }} gab.com Text Pre-treatment and acquired HIV drug resistance in Hunan: a cross-sectional analysis of a growing challenge JO: BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=41131459 #FOAvip BACKGROUND: HIV Drug Resistance (HIVDR) is a key consideration when determining ART regimens. In recent years, Pre-treatment Drug Resistance (PDR) and Acquired Drug Resistance (ADR) have been changing rapidly. We studied the latest PDR and ADR cases in Hunan Province, China. METHOD: The study included People Living With HIV (PLWH) from a hospital in Hunan Province (May 2021?August 2023). Baseline characterisation data were collected from participants. HIV-1 pol sequences were amplified, sequenced, and analyzed for DR mutations, which were analyzed using the Stanford University HIVDR database. Descriptive analysis was used for statistical descriptions. RESULTS: 1,314 PLWH (1,277 successfully tested) were included in the study. Among 917 treatment-naïve PLWH, the most prevalent subtypes were CRF07_BC (41.8%) and CRF01_AE (38.4%), PDR was 14.7% (135/917), with NNRTIs DR rate at 11.6%(mainly NVP 11.6%, EFV 11.1%, RPV 6.7%), NRTIs at 3.6% (mainly ABC 3.4%, 3TC/FTC 3.3%, DDI 1.6%), while INSTIs and PIs remained???1.1%, NNRTIs mutations were most prevalent in V170D/E/L(5.1%) and K238N(3.2%), NRTIs were t in M184I/V(3.3%) and K70E/N/Q/R(0.5%), INSTIs/ PIs were ??0.7%. Among 360 treatment-failure PLWH, the most prevalent subtypes were CRF01_AE (43.1%) and CRF07_BC (26.4%), ADR reached 67.2% (242/360), and NNRTIs DR rate was 54.7%(mainly NVP 54.2%, EFV 52.5%, RPV 38.3%) and NRTIs was 38.1%(mainly 3TC 35.3%, ABC 35.0%, FTC 34.4%,). INSTIs and PIs were ??4.2%, NNRTIs mutations were most prevalent in V170D/E/Q/I/T(20.0%) and K103N/T/R/S(16.9%), NRTIs were in M184I/V(30.8%) and K65R(12.5%), INSTIs/PIs were ??3.3%. CONCLUSION: Both HIV-1 PDR and ADR were challenged in Hunan Province, China. DR testing should be conducted before selecting an ART regimen to guide the initial regimen or develop a more precise regimen. For PLWH who fail to complete DR testing, choosing a regimen containing PIs or INSTIs with a high resistance barrier is more advisable. Twit Text FOAVip Pre-treatment and acquired HIV drug resistance in Hunan: a cross-sectional analysis of a growing challenge ????BMC Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=41131459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131459 #FOAvip English Wikipedia <ref>{{Cite pmid|41131459 }}</ref> Pre-treatment and acquired HIV drug resistance in Hunan: a cross-sectional analysis of a growing challenge #MMPMID41131459 Long S ; Yao R ; Tang Y ; Yu C ; Tang W ; Cao J ; Huang Y ; Lu X ; Li S ; Liu R ; Dai L ; Huang Y ; Zheng F BMC Infect Dis 2025[Oct]; 25 (1 ): 1393 PMID41131459 show ga BACKGROUND: HIV Drug Resistance (HIVDR) is a key consideration when determining ART regimens. In recent years, Pre-treatment Drug Resistance (PDR) and Acquired Drug Resistance (ADR) have been changing rapidly. We studied the latest PDR and ADR cases in Hunan Province, China. METHOD: The study included People Living With HIV (PLWH) from a hospital in Hunan Province (May 2021?August 2023). Baseline characterisation data were collected from participants. HIV-1 pol sequences were amplified, sequenced, and analyzed for DR mutations, which were analyzed using the Stanford University HIVDR database. Descriptive analysis was used for statistical descriptions. RESULTS: 1,314 PLWH (1,277 successfully tested) were included in the study. Among 917 treatment-naïve PLWH, the most prevalent subtypes were CRF07_BC (41.8%) and CRF01_AE (38.4%), PDR was 14.7% (135/917), with NNRTIs DR rate at 11.6%(mainly NVP 11.6%, EFV 11.1%, RPV 6.7%), NRTIs at 3.6% (mainly ABC 3.4%, 3TC/FTC 3.3%, DDI 1.6%), while INSTIs and PIs remained???1.1%, NNRTIs mutations were most prevalent in V170D/E/L(5.1%) and K238N(3.2%), NRTIs were t in M184I/V(3.3%) and K70E/N/Q/R(0.5%), INSTIs/ PIs were ??0.7%. Among 360 treatment-failure PLWH, the most prevalent subtypes were CRF01_AE (43.1%) and CRF07_BC (26.4%), ADR reached 67.2% (242/360), and NNRTIs DR rate was 54.7%(mainly NVP 54.2%, EFV 52.5%, RPV 38.3%) and NRTIs was 38.1%(mainly 3TC 35.3%, ABC 35.0%, FTC 34.4%,). INSTIs and PIs were ??4.2%, NNRTIs mutations were most prevalent in V170D/E/Q/I/T(20.0%) and K103N/T/R/S(16.9%), NRTIs were in M184I/V(30.8%) and K65R(12.5%), INSTIs/PIs were ??3.3%. CONCLUSION: Both HIV-1 PDR and ADR were challenged in Hunan Province, China. DR testing should be conducted before selecting an ART regimen to guide the initial regimen or develop a more precise regimen. For PLWH who fail to complete DR testing, choosing a regimen containing PIs or INSTIs with a high resistance barrier is more advisable. äPre-treatment and acquired HIV drug resistance in Hunan: a cross-secti(epmc).pdf DeepDyve Pubget Overpricing