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10.1186/s12885-025-14694-9 http://scihub22266oqcxt.onion/10.1186/s12885-025-14694-9 C12548223!12548223 !41131505     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131505 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       BMC+Cancer 2025 ; 25 (1 ): 1633 Nephropedia Template TP {{tp|p=41131505 |t=2025. Cyclic cytokines mediated the effect of immune cells on meningioma: a two-step, mediation mendelian randomization study |pdf=|usr=}}{{41131505 }} gab.com Text Cyclic cytokines mediated the effect of immune cells on meningioma: a two-step, mediation mendelian randomization study JO: BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=41131505 #FOAvip BACKGROUND: Meningioma is a common central nervous system tumor that poses serious health hazards and increases with age. However, the role of immune cells in meningioma remains incompletely understood. METHODS: Data from genome-wide association studies on meningioma, cyclic cytokines, and immune cells were comprehensively analyzed. We conducted a two-step, two-sample mendelian randomization study to investigate the causal relationship between immune cell characteristics and meningioma. Furthermore, we examined the mediation effect of cyclic cytokines in connecting the association of immune cells with the risk of meningioma. RESULTS: Eighteen immune phenotypes showed significant correlations with meningioma risk. Notably, Naive CD4-CD8- T cell %T Cell (OR: 1.380, 95% CI: 1.013-1.880, P?=?0.041) and FSC-A on Myeloid Dendritic Cell (OR: 1.177, 95% CI: 1.045-1.325, P?=?0.007) were implicated in promoting meningioma via MMP-1. The mediation effects of MMP-1 in these two immune cells were 0.023 and 0.015, with corresponding proportions of 7.110% and 8.981% in the mediation effect ratio. CONCLUSION: Our study elucidated the causal relationship between immune cell phenotypes and meningioma, pinpointing the potential role of MMP-1. These findings provide clues for potential therapeutic targets. Twit Text FOAVip Cyclic cytokines mediated the effect of immune cells on meningioma: a two-step, mediation mendelian randomization study ????BMC Cancer http://www.kidney.de/pget.php?&tw=1&pmid=41131505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131505 #FOAvip English Wikipedia <ref>{{Cite pmid|41131505 }}</ref> Cyclic cytokines mediated the effect of immune cells on meningioma: a two-step, mediation mendelian randomization study #MMPMID41131505 Huang M ; Liu Y ; Chen C ; Cheng Y ; Dai W BMC Cancer 2025[Oct]; 25 (1 ): 1633 PMID41131505 show ga BACKGROUND: Meningioma is a common central nervous system tumor that poses serious health hazards and increases with age. However, the role of immune cells in meningioma remains incompletely understood. METHODS: Data from genome-wide association studies on meningioma, cyclic cytokines, and immune cells were comprehensively analyzed. We conducted a two-step, two-sample mendelian randomization study to investigate the causal relationship between immune cell characteristics and meningioma. Furthermore, we examined the mediation effect of cyclic cytokines in connecting the association of immune cells with the risk of meningioma. RESULTS: Eighteen immune phenotypes showed significant correlations with meningioma risk. Notably, Naive CD4-CD8- T cell %T Cell (OR: 1.380, 95% CI: 1.013-1.880, P?=?0.041) and FSC-A on Myeloid Dendritic Cell (OR: 1.177, 95% CI: 1.045-1.325, P?=?0.007) were implicated in promoting meningioma via MMP-1. The mediation effects of MMP-1 in these two immune cells were 0.023 and 0.015, with corresponding proportions of 7.110% and 8.981% in the mediation effect ratio. CONCLUSION: Our study elucidated the causal relationship between immune cell phenotypes and meningioma, pinpointing the potential role of MMP-1. These findings provide clues for potential therapeutic targets. |*Cytokines/metabolism/immunology [MESH] |*Meningeal Neoplasms/immunology/genetics [MESH] |*Meningioma/immunology/genetics/pathology [MESH] |Dendritic Cells/immunology [MESH] |Genetic Predisposition to Disease [MESH] |Genome-Wide Association Study [MESH] |Humans [MESH] |Mendelian Randomization Analysis [MESH]Cyclic cytokines mediated the effect of immune cells on meningioma: a (epmc).pdf DeepDyve Pubget Overpricing