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10.1186/s13045-025-01742-x http://scihub22266oqcxt.onion/10.1186/s13045-025-01742-x C12548202!12548202 !41131565     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131565 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Hematol+Oncol 2025 ; 18 (1 ): 87 Nephropedia Template TP {{tp|p=41131565 |t=2025. HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRP? pathway with high safety and preclinical efficacy for hematological and solid tumors |pdf=|usr=}}{{41131565 }} gab.com Text HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRP pathway with high safety and preclinical efficacy for hematological and solid tumors JO: J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=41131565 #FOAvip Cluster of differentiation 47 (CD47) delivers an inhibitory signal that suppresses phagocytosis and prevents immune clearance of tumor cells by interacting with signal regulatory protein alpha (SIRP?) on myeloid cells. Although blockade of the CD47-SIRP? axis is a promising immunotherapeutic strategy, clinical development has been hindered by on-target toxicities (e.g., severe anemia) and insufficient potency. Herein we report a third generation CD47-SIRP? inhibitor HCB101, a rationally designed SIRP?-Fc fusion protein generated from a large-scale screening of a structure-guided SIRP? extracellular domain (ECD) mutant library and fused to a human IgG4 Fc. HCB101 demonstrates high-affinity binding to CD47, robustly promotes macrophage-mediated phagocytosis of tumor cells without affecting red blood cells and exhibits unique advantages over current CD47-targeting agents, including Hu5F9-G4, TTI-622, and ALX148. In multiple xenograft cancer models, HCB101 induced significant inhibition of tumor growth as a single agent and showed synergistic anti-tumor effects when combined with anti-HER2 or anti-EGFR monoclonal antibodies. Additionally, HCB101 treatment increased the M1/M2 macrophage ratio in the tumor microenvironment, suggesting repolarization of tumor-associated macrophages (TAMs) toward a pro-inflammatory phenotype. No dose-limiting toxicities or hematologic adverse effects were observed in murine or non-human primate studies. Twit Text FOAVip HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRP pathway with high safety and preclinical efficacy for hematological and solid tumors ????J Hematol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=41131565 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41131565 #FOAvip English Wikipedia <ref>{{Cite pmid|41131565 }}</ref> HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD47-SIRP? pathway with high safety and preclinical efficacy for hematological and solid tumors #MMPMID41131565 Wang JT ; Tseng CL ; Teng HF ; Kuo PH ; Cheng YC ; Chen YJ ; Lu YH ; Wang CC ; Shen TK ; Wang HF ; Tsai PL ; Wu YC ; Ho CH ; Sun WT ; Li YC ; Lee YH ; Hung YJ ; Chen M ; Li Z ; Juo ZS ; Zhai W ; Liu SS J Hematol Oncol 2025[Oct]; 18 (1 ): 87 PMID41131565 show ga Cluster of differentiation 47 (CD47) delivers an inhibitory signal that suppresses phagocytosis and prevents immune clearance of tumor cells by interacting with signal regulatory protein alpha (SIRP?) on myeloid cells. Although blockade of the CD47-SIRP? axis is a promising immunotherapeutic strategy, clinical development has been hindered by on-target toxicities (e.g., severe anemia) and insufficient potency. Herein we report a third generation CD47-SIRP? inhibitor HCB101, a rationally designed SIRP?-Fc fusion protein generated from a large-scale screening of a structure-guided SIRP? extracellular domain (ECD) mutant library and fused to a human IgG4 Fc. HCB101 demonstrates high-affinity binding to CD47, robustly promotes macrophage-mediated phagocytosis of tumor cells without affecting red blood cells and exhibits unique advantages over current CD47-targeting agents, including Hu5F9-G4, TTI-622, and ALX148. In multiple xenograft cancer models, HCB101 induced significant inhibition of tumor growth as a single agent and showed synergistic anti-tumor effects when combined with anti-HER2 or anti-EGFR monoclonal antibodies. Additionally, HCB101 treatment increased the M1/M2 macrophage ratio in the tumor microenvironment, suggesting repolarization of tumor-associated macrophages (TAMs) toward a pro-inflammatory phenotype. No dose-limiting toxicities or hematologic adverse effects were observed in murine or non-human primate studies. |*Antigens, Differentiation/metabolism [MESH] |*CD47 Antigen/metabolism/antagonists & inhibitors [MESH] |*Hematologic Neoplasms/drug therapy [MESH] |*Immunoglobulin Fc Fragments [MESH] |*Neoplasms/drug therapy/metabolism [MESH] |*Receptors, Immunologic/antagonists & inhibitors/metabolism [MESH] |*Recombinant Fusion Proteins/pharmacology/therapeutic use [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Female [MESH] |Humans [MESH] |Macrophages [MESH] |Mice [MESH] |Phagocytosis/drug effects [MESH] |Signal Transduction/drug effects [MESH]HCB101: a novel potent ligand-trap Fc-fusion protein targeting the CD4(epmc).pdf DeepDyve Pubget Overpricing