Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41131486
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41131486
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 BMC+Endocr+Disord
2025 ; 25
(1
): 240
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Predictors of weight reduction effectiveness with liraglutide in diabetes
mellitus type 2 patients: a retrospective cohort study
#MMPMID41131486
Wangpattanamongkol P
; Manosroi W
BMC Endocr Disord
2025[Oct]; 25
(1
): 240
PMID41131486
show ga
BACKGROUND: GLP-1 receptor agonists (GLP-1RAs) are effective for treating type 2
diabetes mellitus (T2DM) and promoting weight loss, but not all patients respond
similarly. This study aimed to identify predictors of significant weight
reduction at 6 months in T2DM patients treated with liraglutide. MATERIALS AND
METHODS: A retrospective analysis was conducted on 209 T2DM adults prescribed
liraglutide at the Internal Medicine Department, Faculty of Medicine, Chiang Mai
University between January 1, 2017, and December 31, 2022. Patients who could not
tolerate or did not complete titration to 3.0 mg daily were excluded.
Demographic, clinical, anthropometric, and biochemical data were obtained from
electronic medical records. Logistic regression was used to identify clinical and
biochemical factors associated with significant weight reduction (??5% at 6
months), presented as odds ratios (ORs) with 95% confidence intervals (CIs).
Statistical significance was set at p?0.05. RESULTS: Of the 209 patients, 27.3%
achieved significant weight reduction. Lower baseline body mass index (BMI) (OR
1.12, 95% CI 1.01?1.25, p?=?0.036) and greater weight loss at 3 months (OR 2.22,
95% CI 1.67?3.03, p?0.001) were significant predictors of weight reduction at 6
months, after adjusting for age, sex, baseline HbA1c, creatinine, systolic blood
pressure, LDL cholesterol, and concomitant medications. CONCLUSION: Lower
baseline BMI and early weight loss at 3 months predict significant weight
reduction with liraglutide therapy. Identifying these simple, accessible
predictors can improve patient selection and optimize weight control outcomes.