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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Infect+Agent+Cancer
2025 ; 20
(1
): 74
Nephropedia Template TP
gab.com Text
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English Wikipedia
COVID-19 infection and cancer regression: a review of current evidence, potential
mechanisms, and clinical perspectives on a Paradoxical phenomenon
#MMPMID41131532
Ogieuhi IJ
; Ajekiigbe VO
; Agbo CE
; Anthony CS
; Christopher AA
; Onyehalu JC
; Agu MC
; Mbaji SM
; Akingbola A
; Ahmed B
; Ogieuhi O
; Akinmeji O
Infect Agent Cancer
2025[Oct]; 20
(1
): 74
PMID41131532
show ga
Since its emergence, the coronavirus (SARS-CoV-2) outbreak has been a pandemic
responsible for about 7 million deaths worldwide. Numerous studies have been
conducted to determine the virus's multiorgan system involvement, particularly
its relation to cancer biology. Spontaneous regression of cancer has been
observed in some patients with the coronavirus, which may be attributed to the
virus's ability to trigger specific immune responses that can be oncolytic and
help reduce and eliminate oncogenic cells. This study aims to explore the
paradoxical effects of COVID-19 in inducing cancer regression. The paradoxical
effect of SARS-CoV-2 infection has been attributed to the possibility of a
heightened immune activation possibly triggered by the virus, and some of these
include increased levels of cytokines such as interferon and tumor necrosis
factor-alpha (TNF-?), as well as the activation of T cells and natural killer
(NK) cells. COVID-19-induced cancer regression presents new perspectives on the
relationship between viral infections and the immune system's antitumor
capabilities. This would help foster future research investigating specific
immune pathways activated during SARS-CoV-2 and discover how these can be
therapeutically harnessed to aid cancer regression.