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2025 ; 26
(1
): 988
Nephropedia Template TP
gab.com Text
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Exploring feasibility of health-related quality of life assessments and pain
diaries in patients undergoing prehabilitation before total knee arthroplasty: a
pilot study
#MMPMID41131492
Gränicher P
; Kocher M
; de Bie R
; Swanenburg J
; Scherr J
BMC Musculoskelet Disord
2025[Oct]; 26
(1
): 988
PMID41131492
show ga
BACKGROUND: Prehabilitation prior to total knee arthroplasty (TKA) may mitigate
deterioration in health-related quality of life (HRQOL) during the preoperative
period and support recovery after surgery. However, little is known about the
feasibility of systematically monitoring HRQOL and pain through patient-reported
outcome measures (PROMs) in this context. This pilot study aimed to evaluate the
feasibility of using validated HRQOL questionnaires and daily pain diaries during
a prehabilitation programme for patients awaiting (TKA) and up to 12 weeks
postoperatively. METHODS: Twenty patients (mean age 73?±?6 years) scheduled for
primary unilateral TKA were randomly assigned to an intervention group (IG) or
control group (CG). The IG participated in a 4- to 8-week individualised
prehabilitation programme involving exercise and education. Feasibility was
assessed through the completion rates of daily pain diaries and three HRQOL
questionnaires (EQ-5D-5 L, SF-12 and KOOS KRQOL) collected at baseline,
preoperatively, and at 6- and 12-weeks postoperatively. RESULTS: HRQOL
questionnaires demonstrated high completion rates across both groups (90%). In
contrast, adherence to paper-based pain diaries was suboptimal and notably low
(CG: 58%; IG: 47%), falling below the threshold for meaningful analysis.
Consequently, pain trajectory over time could not be reliably assessed. No
significant group-by-time interaction effects were observed for any HRQOL
measure: EQ-5D-5 L (p?=?0.67; F?=?0.51), KOOS KRQOL (p?=?0.72; F?=?0.64), SF-12
PCS (p?=?0.06; F?=?0.50) and MCS (p?=?0.36; F?=?0.10). CONCLUSION: This pilot
study confirms the feasibility and acceptability of HRQOL questionnaires in older
patients undergoing prehabilitation before TKA. However, the low diary completion
rates highlight the need for alternative pain-monitoring-approaches - such as
electronic formats - to improve data quality in future trials. Preliminary
findings suggest potential benefits of prehabilitation, warranting further
investigation in larger studies. TRIAL REGISTRATION: ClinicalTrials.gov
Identifier; NCT05314985. Registered 20 July 2021. BASEC-Nr. 2020-03060.